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WNT beta Catenin Signaling Pathway  WNT beta Catenin Signaling Pathway

The WNT beta catenin signaling pathway is an evolutionarily conserved signal transduction pathway that regulates a wide range of cellular functions like differentiation, proliferation, embryonic growth, stem cell development, immune cell functions, epithelial-mesenchymal transition (EMT), metabolism, cell fate and tissue repair and regeneration (1,2).


Wnt/β-Catenin Signaling: The Culprit in Pancreatic Carcinogenesis and Therapeutic Resistance (5)

WNT beta catenin signaling Pathway  WNT beta catenin signaling Pathway and diseases

Due to its involvement in key biological process, several studies reveal and confirm the key roles of dysregulated Wnt signaling in cancer initiation and progression, and drug resistance (2,3,5).
The WNT pathway has emerged as a key contributor to a variety of diseases such as fibrosis (2), Alzheimer, metabolic diseases, aging, cardiovascular diseases, neuronal diseases (6), obesity and diabetes by affecting the metabolism of normal cells (4).

WNT Signaling in Disease (6)

(1) Haseeb M et al. Wnt Signaling in the Regulation of Immune Cell and Cancer Therapeutics. Cells. (2019)3;8(11)..
(2) Lecarpentier Y et al. Multiple Targets of the Canonical WNT/β-Catenin Signaling in Cancers. Front Oncol. (2019)18;9:1248..
(3) Zhong Z et Virshup DM. Wnt signaling and drug resistance in cancer. Mol Pharmacol. (2019)1.
(4) Mo Y et al. The role of Wnt signaling pathway in tumor metabolic reprogramming. J Cancer. (2019)9;10(16):3789-3797.
(5) Ram Makena M et al. Wnt/β-Catenin Signaling: The Culprit in Pancreatic Carcinogenesis and Therapeutic Resistance. Int J Mol Sci. (2019)30;20(17).
(6) Ng LF et al. WNT Signaling in Disease. Cells. (2019)3;8(8).
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