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The ERBB signaling pathway, also known as the Epidermal Growth Factor Receptor (EGFR) family, plays a crucial role in regulating a variety of cellular processes, including growth, survival, differentiation, and migration. This pathway consists of four receptors ERBB1 (EGFR), ERBB2 (HER2), ERBB3 (HER3), and ERBB4 (HER4) which interact with several ligands like EGF, TGF-alpha, and heregulin to trigger complex intracellular signaling cascades.
AnyGenes® provides cutting-edge qPCR arrays specifically designed to analyze the ERBB signaling pathway with high precision. Our advanced tools enable researchers to investigate gene expression changes in key components of the ERBB pathway, such as EGFR, HER2, and downstream signaling molecules like PI3K, MAPK, and AKT. By providing accurate and reproducible results, AnyGenes® qPCR arrays allow for in-depth analysis of the pathway's role in various diseases, particularly cancer and tissue regeneration.
ErbB receptors and their ligands. ErbB2 has no known ligand, while ErbB3 lacks intrinsic kinase activity (indicated by a cross). Following ligand binding, the receptors activate several downstream signaling pathways thereby regulating cell growth, proliferation, and survival. These processes play an important role in development, wound healing and tissue regeneration. EGF, epidermal growth factor; TGFα, transforming growth factor-α; EPG, epigen; AREG, amphiregulin; EREG, epiregulin; BC, betacellulin; HB-EGF, heparin-binding EGF-like growth factor; NRG1-4, neuregulin 1-4; STAT, signal transducer and activator of transcription; MAPK/ERK, mitogen-activated protein kinase/extracellular signal-regulated kinase; PIK3/Akt, phosphoinositide 3-kinase/protein kinase B; PLCγ, phospholipase Cγ.
The ERBB receptors signal through multiple pathways, including:
ERBB signaling can occur through autocrine mechanisms, where cells produce ligands that activate their own receptors, or paracrine signaling, where ligands affect neighboring cells. This versatility allows for rapid responses to environmental changes and is critical in tumor progression.
The ERBB signaling pathway is implicated in various cancers, particularly breast, lung, and head and neck cancers. Aberrant activation of this pathway, often due to mutations or overexpression of EGFR and HER2, can lead to uncontrolled cell growth and metastasis. Targeted therapies, such as monoclonal antibodies and small molecules that inhibit EGFR and HER2, are commonly used to treat cancers driven by ERBB signaling.
Beyond cancer, the ERBB pathway is critical in tissue repair and regeneration. It is involved in wound healing and organ regeneration by promoting cell migration, survival, and differentiation. Understanding the molecular mechanisms of ERBB signaling can pave the way for therapeutic strategies to enhance tissue regeneration following injury or in degenerative diseases.
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ERBB Signaling Pathway |
ERBB1H1 |
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ERBB Signaling Pathway |
ERBB1M1 |
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ERBB Signaling Pathway |
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ERBB Signaling Pathway |
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