Logout
If you want to log out click in LogOut
Lymphangiogenesis is the biological process through which new lymphatic vessels are formed from pre-existing ones. This phenomenon is crucial for maintaining fluid homeostasis, facilitating immune cell trafficking, and supporting tissue repair. It plays a significant role in various physiological and pathological conditions, including inflammation, tumor metastasis, and cardiovascular diseases.
AnyGenes qPCR arrays enhance research in the lymphangiogenesis by providing accurate gene expression data related to lymphatic vessel formation. These tools enable researchers to identify key biomarkers associated with lymphangiogenesis, paving the way for targeted therapies for lymphatic disorders like lymphedema and certain cancers.
Growth factor and cytokine signaling pathways in lymphangiogenesis. Growth factors derived from tumor cells, inflammatory cells, or other cell types activate their receptors on the surface of LECs and initiate various signaling cascades, leading to lymphatic vessel growth. Coordinately, these factors regulate cell migration, proliferation, and survival and vessel dilation and remodeling. Interactions between adjacent LECs via ANG/TIE2, DLL4/Notch1, and EFNB2/EPHB4 also contribute to the regulation of lymphangiogenic activity. Note that in contrast to ANG1, ANG2 is predominantly an autocrine ligand and that both angiopoietins bind with equal affinity to TIE2 and induce in trans ligand receptor complexes among ECs (103). Inhibitors that target the various involved molecules are indicated in red, and some of the key signaling consequences in blue.
The process of lymphangiogenesis can be categorized into two main types.
Key factors influencing the formation of new lymphatic vessels include:
The formation of new lymphatic vessels is vital for several physiological processes:
In pathological contexts, dysregulation of lymphangiogenesis can contribute to conditions such as:
Tumors often promote formation of new lymphatic vessels, allowing cancer cells to escape the primary tumor site and spread through the lymphatic system. This process not only facilitates metastasis but also alters the tumor microenvironment, impacting immune responses. Studies have shown that the formation of new lymphatic vessels often occurs in the draining lymph nodes before the arrival of metastatic cells, suggesting that tumors can create a pre-metastatic niche conducive to metastasis.
Research into the formation of new lymphatic vessels has opened new avenues for therapeutic interventions. Targeting specific growth factors and signaling pathways may offer potential strategies for enhancing lymphatic function in conditions like lymphedema or inhibiting the formation of new lymphatic vessels in cancer to prevent metastasis. Moreover, advancing our understanding of lymphangiogenic processes could lead to novel treatments for inflammatory diseases and wound healing therapies.
Customize your own signaling pathways (SignArrays®) with the factors of your choice!
Simply download and complete our Personalized SignArrays® information file
and send it at
contact@anygenes.com
to get started on your project.
| Signaling Pathways | Product ref | Informations |
|---|---|---|
|
Lymphangiogenesis |
LA1H1 |
| Signaling Pathways | Product ref | Informations |
|---|---|---|
|
Lymphangiogenesis |
LA1M1 |
| Signaling Pathways | Product ref | Informations |
|---|---|---|
|
Lymphangiogenesis |
******* |
|
| Signaling Pathways | Product ref | Informations |
|---|---|---|
|
Lymphangiogenesis |
******* |
|