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Signaling Pathways title  NOTCH Signaling Pathway

Notch signaling is a highly conserved signaling pathway that regulates cell proliferation and differentiation, stem-cell renewal (pancreatic, hematopoietic, neural, and skeletal muscle systems), survival, apoptosis, tissue patterning, determines cell fate decision, and participates in cellular process in embryonic and adult tissue (1,2).

Intracellular Notch signaling cascade

Intracellular Notch signaling cascade (3)

The Notch pathway is a major regulator of cardiovascular function and it is also implicated in several biological processes mediating viral infections. Therefore, new therapies could target Notch to fight heart and lung diseases caused directly by SARS-CoV-2 infection and the cytokine storm in response to the virus (3).

Signaling Pathways title  NOTCH pathway and diseases

Notch pathway has been implicated in many pathological conditions, including inflammatory diseases (rheumatoid arthritis…..), immunity (4), respiratory diseases such as pulmonary artery hypertension (PAH), chronic obstructive pulmonary disease (COPD), interstitial pulmonary fibrosis (IPF), and lung cancer (5). Recent Studies suggest that the dysregulation of the Notch pathway contributes to carcinogenesis, cancer stem cell renewal, angiogenesis, and chemo-resistance (2).
(1) Luo Z et al. Notch Signaling in Osteogenesis, Osteoclastogenesis, and Angiogenesis. Am J Pathol. (2019);189(8):1495-1500.
(2) Han J & al. Regulation of Adipogenesis Through Differential Modulation of ROS and Kinase Signaling Pathways by 3,4'-Dihydroxyflavone Treatment. J Cell Biochem. (2017);118(5):1065-1077.
(3) Zhang Z1 & Scherer PE. Adipose tissue: The dysfunctional adipocyte - a cancer cell's best friend. Nat Rev Endocrinol. (2018);14(3):132-134.
(4) Duong MN & al. The fat and the bad: Mature adipocytes, key actors in tumor progression and resistance. Oncotarget. (2017).
(5) Choi J & al. Adipocyte biology in breast cancer: From silent bystander to active facilitator. Prog Lipid Res. (2018);(69):11-20.
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