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Nitric Oxide pathway  Nitric Oxide pathway

Nitric oxide pathway with its central component Nitric Oxide (NO) is a potent signaling molecule involved in the regulation of various cellular mechanisms and pathways under normal and pathological conditions including immune, cardiovascular, reproductive, neuromuscular, and nervous system function, vasodilation, neurotransmission, cell migration, and apoptosis.

NO exerts numerous effects on the kidneys, heart and vasculature as well as on peripheral metabolically active organs (1,2,3).

Nitric-Oxide-Pathway

 
The NOS pathway and potential effects of NO on cardiovascular,renal and metabolic functions (2).


Nitric Oxide pathway  Nitric oxide and diseases

NO has a complex and multifaceted role in cancer (breast, lung, prostate, colon, gastric, pancreatic, ovarian, and neuroblastoma), aging, cardiovascular pathogenesis, ocular hypertension, Glaucoma … (3,4,5,6).
(1) Kopp-Scheinpflug C et al. Nitric Oxide Signaling in the Auditory Pathway. Front Neural Circuits. (2021);15:759342.
(2) Carlström M. Nitric oxide signalling in kidney regulation and cardiometabolic health.Nat Rev Nephrol. (2021);17(9):575-590.
(3) López-Sánchez LM et al. Nitric oxide and tumor metabolic reprogramming. Biochem Pharmacol. (2020);176:113769.
(4) Pourbagher-Shahri AM et al. An Overview of NO Signaling Pathways in Aging. Molecules. (2021);26(15):4533.
(5) Liu X et al. Protein Phosphorylation in Cancer: Role of Nitric Oxide Signaling Pathway. Biomolecules. (2021);11(7):1009.
(6) Reina-Torres E et al. The vital role for nitric oxide in intraocular pressure homeostasis. Prog Retin Eye Res. (2021);83:100922
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