CELL MOTILITY AND ITS ROLE IN CELLULAR PROCESSES

Cell motility refers to the ability of cells to move and navigate through their environment. This movement is essential for many physiological processes, such as embryonic development, wound healing and immune responses. Disruption in cell movement can lead to diseases, including cancer metastasis. AnyGenes innovative products are designed to support research into the mechanisms of cell motility, focussing on the key signaling pathways that regulate these processes.

Discover our advanced qPCR arrays for Cell Motility research.

Signaling pathway and cell migration.

SIGNALING PATHWAYS GOVERNING CELL MOTILITY

The regulation of cell migration is tightly controlled by a series of signaling pathways.

Rho GTPase: central to the regulation of actin cytoskeleton dynamics, Rho family GTPases (RhoA, Rac1, Cdc42) orghestrate cellular processes that drive migration.
Actin dynamics
Integrin-mediated adhesion
Chemotactic signals: other important signaling pathways, involve growth factors, chemokines and integrins, including the PI3K/AKT pathway and MAPK/ERK pathway.

KEY COMPONENTS OF THE CELL MIGRATION PATHWAY

Cell mobility is a complex process involving various components that work together to enable cells to move.

Cytoskeletal elements: including actin filaments, microtubules, intermediate filaments.
Signaling molecules: including Rho GTPases (RhoA, Rac1, Cdc42), growth factors and cytokines.
Adhesion molecules: such as integrins.
Motor proteins: like myosin.
Plasma membrane dynamics
Intracellular signaling pathways

THE ROLE OF CELL MOBILITY IN CANCER METASTASIS

In cancer, abnormal cell movement contributes to metastasis, where cancer cells move from the original tumor site to other parts of the body. Understanding the signaling pathways involved in this process is critical for developing therapeutic interventions.

Our SignArrays ^® products are tailored to help researchers explore these complex interactions at the molecular level.

CELL MOTILITY AND THERAPEUTICS APPROACHES

Understanding how cells move and respond to their environment provides insights into treating conditions like cancer, autoimmune diseases and tissue regeneration. In cancer therapy, targeting cell movement is key to preventing tumor metastasis. In would healing and tissue repair, promoting cell mobility can enhance recovery by encouraging cells to migrate to damaged areas, facilitating regeneration.

Merino-Casallo et al. Unravelling cell migration: defining movement from the cell surface. Cell Adh Migr. 2022 May 1;16(1):25–64.
Devreotes P & Horwitz AR. Signaling Networks that Regulate Cell Migration. Cold Spring Harb Perspect Biol. (2015);7(8):a005959.

CELL MOTILITY BIOMARKER LIST

Customize your own signaling pathways (SignArrays^®) with the factors of your choice!
Simply download and complete our Personalized SignArrays^® information file and send it at [email protected] to get started on your project.

You can check the biomarker list included in this pathway, see below:

Species : Homo sapiens (human)

Human Cell Motility

Signaling Pathways	Product ref	Informations
Cell Motility	CM1H1	List infos

Species : Mus musculus (mouse)

Mouse signaling pathways

Signaling Pathways	Product ref	Informations
Cell Motility	CM1M1	List infos

Species : Rattus norvegicus (rat)

Rat signaling pathways

Signaling Pathways	Product ref	Informations
Cell Motility	*******	List In progress...

Species : Sus Scrofa (Pig)

Pig Cell Invasion

Signaling Pathways	Product ref	Informations
Cell Motility	*******	List In progress...

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