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PI3K-AKT pathway  PI3K-AKT pathway

PI3K-AKT pathway is one of the most important pathways that control many cellular processes including, cell division, autophagy, survival, proliferation, migration, differentiation, angiogenesis, apoptosis, metabolism and protein synthesis (1,4).


Upstream activation of the PI3K/Akt signaling pathway (2)

PI3K-Akt pathway  PI3K-Akt pathway and diseases

The PI3K/Akt signaling pathway controls hallmarks of cancer, including cell survival, metastasis and metabolism (2), in adition to its important role in multidrug resistance in a variety of cancers, such as breast cancer, leukemia, lung cancer, ovarian cancer, hepatocellular carcinoma, and melanoma (3). PI3K/Akt signaling is implicated in numerous pathologies like skin diseases, autoimmune diseases, neurodegenerative diseases and brain tumor metastasis…(4,5).
(1) Jafari M et al. PI3k/AKT signaling pathway: Erythropoiesis and beyond. J Cell Physiol. (2019);234(3):2373-2385.
(2) He Y et al. Targeting PI3K/Akt signal transduction for cancer therapy. Signal Transduct Target Ther. (2021);6(1):425.
(3)Liu R et al. PI3K/AKT pathway as a key link modulates the multidrug resistance of cancers. Cell Death Dis. (2020);11(9):797.
(4) Teng Y et al. The PI3K/Akt Pathway: Emerging Roles in Skin Homeostasis and a Group of Non-Malignant Skin Disorders. Cells. (2021);10(5):1219.
(5) Chu E et al. Dysregulated phosphoinositide 3-kinase signaling in microglia: shaping chronic neuroinflammation. J Neuroinflammation. (2021);18(1):276.
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