EGF-PDGF SIGNALING PATHWAY: KEY DRIVERS IN CELL GROWTH AND REGENRATION

The EGF-PDGF signaling pathway is a complex network of molecular interactions that play a vital role in regulating various cellular processes. Epidermal Growth Factor (EGF) and Platelet-Derived Growth Factor (PDGF) are critical regulators of cell growth, differentiation and survival.

AnyGenes offers advanced SignArrays® designed for the high-throughput analysis of key components withing the EGF-PDGF pathways.These customizable qPCR arrays provide researchers with the tools to study these pathways in detail, contributing to breakthroughs in cancer research, regenerative medicine and targeted therapies.

AnyGenes SignArrays® for high-throughput analysis of EGF-PDGF signaling pathways in various research applications

Discover our advanced qPCR arrays for EGF-PDGF Signaling Pathway research.

Signaling by EGF and PDGF in the regulation of β-cell proliferation.

SIGNALING PATHWAY: KEY COMPONENTS

EGF signaling pathway: activated when EGF binds to its receptor tirosine kinase, EGFR (Epidermal Growth Factor Receptor),
PDGF signaling pathway: activated by the binding of PDGF to its receptors, PDGFRA and PDGFRB.

MECHANISM OF ACTION OF EGF-PDGF PATHWAY

Receptor activation: Both EGF and PDGF receptors undergo dimerization upon ligand binding, which is essential for their activation. This process involves specific immunoglobulin-like domains that stabilize the receptor interactions.
Downstream signaling: Cascade of intracellular signals that promote cell proliferation and survival. Among these cascades, MAPK/ERK, PI3K/AKT, JAK/STAT, RAS/MAPK, PI3K and PLCγ pathways, all of which contribute to controlling cell division and differentiation.

SIGNALING IMPACT IN HEALTH AND DISEASES

The EGF-PDGF pathways play a crucial role in regulating cell growth, survival, migration, embryonic development, tissue repair and angiogenesis. However, when these pathways are dysregulated, they can contribute to various diseases including cancer, cardiovascular conditions, atherosclerosis, and fibrosis.

THERAPEUTIC IMPLICATION

Targeting the EGF-PDGF pathway represents a promising strategy for cancer treatment. Inhibitors that block these pathways are being explored for their potential to reduce tumor growth and improve patient outcomes.

Understanding the interplay between these growth factors can lead to more effective combination therapies that disrupt multiple signaling routes involved in cancer progression.

(1) Sun Z, et al. Predominant control of PDGF/PDGF receptor signaling in the migration and proliferation of human adipose‑derived stem cells under culture conditions with a combination of growth factors. Exp Ther Med. (2024)21;27(4):156.

(2) Pandey P, et al. New insights about the PDGF/PDGFR signaling pathway as a promising target to develop cancer therapeutic strategies. Biomed Pharmacother. (2023):161:114491.

(3) Moench R, et al. Platelet-derived growth factor (PDGF) cross-signaling via non-corresponding receptors indicates bypassed signaling in colorectal cancer. Oncotarget. (2022)19;13:1140-1152.

(4) Bernal-Mizrachi E, et al. Human β-cell proliferation and intracellular signaling part 2: still driving in the dark without a road map. Diabetes. (2014)13;63(3):819–831.

(5) Heldin CH. Targeting the PDGF signaling pathway in tumor treatment. Cell Commun Signal. (2013)20;11:97.

EGF-PDGF SIGNALING PATHWAY BIOMARKER LIST

Customize your own signaling pathways (SignArrays®) with the factors of your choice!
Simply download and complete our Personalized SignArrays® information file and send it at contact@anygenes.com to get started on your project.

You can check the biomarker list included in this pathway, see below:

Species : Homo sapiens (human)

Signaling Pathways	Product ref	Informations
EGF-PDGF Signaling Pathway	EGF1H1	List infos

Species : Mus musculus (mouse)

Signaling Pathways	Product ref	Informations
EGF-PDGF Signaling Pathway	EGF1M1	List infos

Species : Rattus norvegicus (rat)

Signaling Pathways	Product ref	Informations
EGF-PDGF Signaling Pathway	*******	List In progress...

Species : Sus Scrofa (Pig)

Signaling Pathways	Product ref	Informations
EGF-PDGF Signaling Pathway	*******	List In progress...

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