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Signaling Pathways title  Hypoxia

Hypoxia refers to a condition in which oxygen is limited. It is mainly related to pathological situations, but it can also be a part of normal physiology. Hypoxic responses are controlled by hypoxia-inducible factors (HIFs) (1,4).


Hypoxia-inducible factor (HIF) regulation during normoxia and hypoxia (1)

Signaling Pathways title  Deficiency of oxygen and diseases

An adequate concentration of oxygen is required by eukaryotic cells to maintain a variety of biological activities and ensure survival. Oxygen starvation represents a frequent player in a number of malignancies, contributing to the development of the neoplastic disease such as liver cancer, and innate immunity, aging, COVID-19, heart disease, pulmonary disease, kidney disease…(1,2,3,4,5)
(1) Lee JW et al. Hypoxia signaling in human diseases and therapeutic targets. Exp Mol Med. (2019);51(6):1-13.
(2) Tirpe AA et al. Hypoxia: Overview on Hypoxia-Mediated Mechanisms with a Focus on the Role of HIF Genes. Int J Mol Sci. (2019);20(24):6140.
(3) Yuen VW, Wong CC. Hypoxia-inducible factors and innate immunity in liver cancer.J Clin Invest. (2020);130(10):5052-5062.
(4) Yeo EJ. Hypoxia and aging. Exp Mol Med. (2019);51(6):1-15.
(5) Serebrovska ZO et al. Hypoxia, HIF-1α, and COVID-19: from pathogenic factors to potential therapeutic targets. Acta Pharmacol Sin. (2020);41(12):1539-1546.
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