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Signaling Pathways title  T Helper Cells, immune system alarm

CD4+ T cells are the central element of the adaptive immune responses and protect the body from a variety of pathogens by helping B lymphocytes to produce antibodies (Ab) and by secreting specific cytokines that provide efficient protection against pathogens (1,3).

CD4+ T cells development and their functional subsets in immunity (4)

Signaling Pathways title  T helper (Th) cells and diseases

CD4+ T helper (Th) cells play pivotal roles in many inflammatory and autoimmune diseases such as multiple sclerosis (MS), rheumatoid arthritis (RA), psoriasis, inflammatory bowel diseases, viral infections and tumorigenesis (1,2,3,4).

(1) Wan Z, et al. Regulatory T cells and T helper 17 cells in viral infection. Scand J Immunol. (2020);91(5):e12873.
(2) Yasuda K, et al. The pathogenicity of Th17 cells in autoimmune diseases. Semin Immunopathol. (2019);41(3):283-297.
(3) Kunkl M, et al. T Helper Cells: The Modulators of Inflammation in Multiple Sclerosis. Cells. (2020);9(2):482.
(4) Basu A, et al. Differentiation and Regulation of T H Cells: A Balancing Act for Cancer Immunotherapy. Front Immunol. (2021);12:669474.
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