T Helper 17 (Th17) cells are a distinct subset of CD4+ T cells that play a critical role in the immune system by producing a variety of pro-inflammatory cytokines, including interleukin-17 (IL-17), IL-21, and IL-22. These cells are essential for host defense against extracellular pathogens, particularly bacteria and fungi, and are implicated in the pathogenesis of several autoimmune and inflammatory diseases.
AnyGenes offers advanced qPCR array products specifically designed to investigate key biomarkers and signaling pathways associated with T Helper 17 cell activation and function. Our qPCR arrays provide researchers with valuable tools to explore gene expression profiles critical for understanding the role of Th17 cells in health and disease.
he plasticity of T helper 17 cells. TH17 cell plasticity and its beneficial (left) or detrimental (right)effects on host immunity depend on the type of challenge faced by the host.
The differentiation of naive CD4+ T cells into Th17 cells is primarily driven by specific cytokines present in the environment. Key cytokines involved in this process include:
The Th17 signaling pathway involves several crucial steps:
Th17 cells are implicated in various diseases, including:
Research into Th17 cells and cytokine signaling offers promising avenues for therapeutic interventions, particularly in autoimmune and inflammatory diseases. Targeting Th17 cell pathways, such as the IL-17 and IL-23 axes, has shown potential in reducing inflammation and controlling immune responses. This approach could help manage conditions like psoriasis, rheumatoid arthritis, and multiple sclerosis.
Additionally, modulating Th17 cell activity may enhance therapies for infections where a robust immune response is crucial. By focusing on these signaling pathways, therapies can be developed to precisely balance immune activation, potentially minimizing side effects and improving patient outcomes.
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