UNDERSTANDING THE IL6 STAT3 SIGNALING PATHWAY

The IL6 STAT3 signaling pathway is a critical regulator of immune responses, inflammation, and cellular proliferation. It plays a central role in numerous physiological processes, including tissue repair, hematopoiesis, and defense against infections. Dysregulation of this pathway has been implicated in various diseases such as cancer, autoimmune disorders, and chronic inflammatory conditions.

Why choose AnyGenes® for IL-6/STAT3 pathway research?

AnyGenes® offers advanced qPCR arrays specifically designed for studying the IL6/STAT3 signaling pathway. With our solutions, researchers can:

Investigate key regulators like IL6, JAK1, JAK2, and STAT3.
Analyze downstream target genes such as VEGF, MMPs, and SOCS3.
Explore interactions between the IL-6/STAT3 pathway and other signaling pathways, such as PI3K/Akt and NF-κB.

Our qPCR arrays are engineered for precision, reproducibility, and reliability, delivering dependable results for uncovering complex biological mechanisms.

AnyGenes® IL6 STAT3 signaling pathway qPCR array for gene expression analysis and inflammation research.

Discover our advanced qPCR arrays for IL-6 STAT3 pathway research.

IL6 AND STAT3: CRITICAL BIOMARKERS IN BIOLOGY

IL6

Interleukin-6 (IL-6) is a multifunctional cytokine involved in immunity, tissue regeneration, and metabolism. However, excessive IL6 production and dysregulated receptor signaling contribute to the pathology of acute inflammation, autoimmune diseases, and tumor development.

STAT3

Signal Transducer and Activator of Transcription 3 (STAT3) is a key transcription factor that regulates the biology of normal and transformed cells. STAT3 is especially significant in the regulation of both normal and cancer stem cells, influencing cellular survival, proliferation, and differentiation.

Signalling downstream of the IL-6 receptor.

MECHANISM OF ACTION AF IL6 STAT3 PATHWAY

IL6 Activation: IL6 binds to its receptor, triggering JAK-mediated phosphorylation of STAT3 via JAK1, JAK2, or TYK2.
STAT3 Translocation: Phosphorylated STAT3 translocates to the nucleus, where it regulates genes involved in inflammation, cell survival, and proliferation.
Crosstalk with Other Pathways: The IL-6/STAT3 pathway interacts with PI3K/Akt and NF-κB signaling, amplifying its role in inflammation and cancer progression.

BIOLOGICAL FUNCTIONS OF THE IL-6/STAT3 SIGNALING PATHWAY

This pathway is pivotal for:

Inflammation Regulation: Modulating acute-phase responses and cytokine production.
Tissue Repair: Promoting cell proliferation and regeneration during injury.
Cancer Progression: Supporting tumor growth, survival, and metastasis.
Immune System Balance: Maintaining equilibrium between pro-inflammatory and anti-inflammatory signals.

DISEASES ASSOCIATED WITH IL6/STAT3 SIGNALING DYSREGULATION

Aberrations in the IL6/STAT3 pathway contribute to numerous diseases:

Cancer: Drives tumor progression, angiogenesis, and immune evasion.
Autoimmune Disorders: Sustains chronic inflammation in diseases like rheumatoid arthritis, lupus, and psoriasis.
Metabolic Diseases: Influences obesity, insulin resistance, and associated complications.
Cardiovascular Diseases: Plays a role in inflammation and tissue remodeling in conditions like atherosclerosis and heart failure.

APPLICATIONS OF IL6/STAT3 PATHWAY RESEARCH

Drug Development: Understanding this pathway aids in identifying therapeutic targets for cancer and inflammatory diseases.
Biomarker Discovery: IL6 and STAT3 serve as biomarkers for disease progression and response to treatment.
Personalized Medicine: Insights into this pathway can guide tailored therapies for autoimmune disorders and cancer.

(1) Kang S, et al. Targeting Interleukin-6 Signaling in Clinic. Immunity. (2019) 16;50(4):1007-1023.

(2) Song Z, et al. Molecular cross-talk of IL-6 in tumors and new progress in combined therapy. Thorac Cancer. (2018);9(6):669-675.

(3) Galoczova M, et al. STAT3, stem cells, cancer stem cells and p63. Cell Mol Biol Lett. (2018)22;23:12.

(4) Johnson DE, et al. Targeting the IL-6/JAK/STAT3 signalling axis in cancer. Nat Rev Clin Oncol. (2018);15(4):234-248.

(5) Yan Lin et al. Progress in Understanding the IL-6/STAT3 Pathway in Colorectal Cancer. Onco Targets Ther. (2020)21;13:13023-13032.

(6) Moshapa FT, et al. Therapeutic Targeting of the Proinflammatory IL-6-JAK/STAT Signalling Pathways Responsible for Vascular Restenosis in Type 2 Diabetes Mellitus. Cardiol Res Pract. (2019)2;2019:9846312.

(7) Liu Y, et al. STAT3 and its targeting inhibitors in osteosarcoma. Cell Prolif. (2021);54(2):e12974.

(8) Kasembeli MM, et al. Contribution of STAT3 to Inflammatory and Fibrotic Diseases and Prospects for its Targeting for Treatment. Int J Mol Sci. (2018)5;19(8):2299.

(9) Mohrherr J, et al. STAT3: Versatile Functions in Non-Small Cell Lung Cancer. Cancers (Basel). (2020)29;12(5):1107.

IL6 STAT3 SIGNALING PATHWAY BIOMARKER LIST

Customize your own signaling pathways (SignArrays®) with the factors of your choice!
Simply download and complete our Personalized SignArrays® information file and send it at contact@anygenes.com to get started on your project.

You can check the biomarker list included in this pathway, see below:

Species : Homo sapiens (human)

Signaling Pathways	Product ref	Informations
IL6-STAT3 Signaling Pathway	IL61H1	List infos

Species : Mus musculus (mouse)

Signaling Pathways	Product ref	Informations
IL6-STAT3 Signaling Pathway	IL61M1	List infos

Species : Rattus norvegicus (rat)

Signaling Pathways	Product ref	Informations
IL6-STAT3 Signaling Pathway	*******	List In progress...

Species : Sus Scrofa (Pig)

Signaling Pathways	Product ref	Informations
IL6-STAT3 Signaling Pathway	*******	List In progress...

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