CYTOKINES: KEY REGULATORS OF IMMUNE SIGNALING AND INFLAMMATION

Cytokines are small, soluble proteins secreted by immune cells that act as messengers in the body. These signaling molecules regulate immune responses, inflammation, and cell communication, making them critical for maintaining health and responding to disease. Immune mediators interact with specific receptors on target cells, triggering signaling pathways that influence processes like cell growth, differentiation, and survival.

AnyGenes® offers advanced qPCR arrays and tools tailored for cytokine research. With unmatched precision and sensitivity, AnyGenes® products enable researchers to explore cytokine-mediated pathways involved in immunity, inflammation, and disease. Whether investigating pro-inflammatory markers, anti-inflammatory markers, or cytokine dysregulation in disease states, AnyGenes® qPCR arrays deliver reliable results for cutting-edge discoveries.

AnyGenes® cytokines qPCR array for precise cytokine expression analysis in immune response and disease research.

Discover our advanced qPCR arrays for Cytokines research.

Cytokines, chemokines and receptors, their effector T cells
and inflammatory mechanisms.

FUNCTIONS AND TYPES OF CYTOKINES

Immune mediators can be classified into various groups based on their function:

Pro-inflammatory Cytokine: Promotes inflammation during infection or injury (e.g., IL-1, IL-6, TNF-α).
Anti-inflammatory Cytokine: Counteracts inflammation to maintain homeostasis (e.g., IL-10, TGF-β).
Interleukins (ILs): Facilitate communication between leukocytes and regulate immune responses.
Chemokines: Guide cell migration during immune surveillance and tissue repair.
Interferons (IFNs): Protect cells from viral infections and modulate immune activity.

CYTOKINE SIGNALING PATHWAYS

Immune mediators activate a variety of signaling pathways that govern biological responses:

JAK-STAT Pathway: Key in immune responses, it transmits signals from cytokine receptors to the nucleus, influencing gene expression.
MAPK Pathway: Regulates cellular responses such as proliferation, differentiation, and apoptosis.
NF-κB Pathway: Plays a central role in inflammation and immune regulation.
PI3K-Akt Pathway: Involved in cell survival, growth, and metabolism.

AnyGenes® qPCR arrays are designed to facilitate the study of these pathways, providing accurate insights into cytokine-mediated signaling and its implications in health and disease.

CYTOKINES AND DISEASE PROGRESSION

Cytokine imbalances are linked to numerous pathological conditions, from chronic inflammation to cancer progression. Overproduction of pro-inflammatory cytokines can lead to cytokine storms, a life-threatening immune overreaction seen in diseases like sepsis and severe viral infections. Conversely, insufficient cytokine activity can compromise immune responses, leaving the body vulnerable to infections and disease.

AnyGenes® offers innovative qPCR arrays tailored to investigate cytokine dysregulation, providing researchers with reliable tools to understand these mechanisms and develop targeted therapies.

CYTOKINES IN THERAPEUTICS AND BIOMARKER RESEARCH

These immune mediators are valuable biomarkers for diagnosing and monitoring diseases. They also represent promising targets for therapeutic interventions:

Cytokine Inhibitors: Used to block pro-inflammatory cytokine in autoimmune diseases (e.g., TNF-α inhibitors for rheumatoid arthritis).
Cytokine Therapy: Leveraging cytokines like IFN-α and IL-2 to treat conditions such as cancer and viral infections.
Cytokine Biomarkers: Used in diagnostics and personalized medicine to track disease progression and treatment response.

AnyGenes® cutting-edge qPCR tools enable precise detection and quantification of cytokine biomarkers, accelerating research in diagnostics and therapeutics.

Explore the role of cytokines in diseases with AnyGenes® qPCR arrays. Understand their impact on immune response, inflammation, and disease progression.

Interactions between tumor cells and infiltrating immune cells
in the tumor microenvironment.

(1) R.A.Prell, J.M.Tarrant. Cytokines: Role in Homeostasis and Disease States. (2018) 428-466..

(2) Lierova A et al. Cytokines and radiation-induced pulmonary injuries. J Radiat Res. (2018) 31.

(3) Monastero RN et Pentyala S. Cytokines as Biomarkers and Their Respective Clinical Cutoff Levels. Int J Inflam. (2017).

(4) Méndez-García LA et al. Breast Cancer Metastasis: Are Cytokines Important Players During Its Development and Progression? J Interferon Cytokine Res. (2018) 13.

(5) Setrerrahmane S, Xu H. Tumor-related interleukins: old validated targets for new anti-cancer drug development. Mol Cancer. (2017) 19;16(1):153.

(6) Kothur K et al. Cytokines in CSF cytokines/chemokines as biomarkers in neuroinflammatory CNS disorders: A systematic review. Cytokine. (2016);77:227-37.

CYTOKINES SIGNALING PATHWAY BIOMARKER LIST

Customize your own signaling pathways (SignArrays®) with the factors of your choice!
Simply download and complete our Personalized SignArrays® information file and send it at contact@anygenes.com to get started on your project.

You can check the biomarker list included in this pathway, see below:

Species : Homo sapiens (human)

Signaling Pathways	Product ref	Informations
Cytokines	CT1H1	List infos

Species : Mus musculus (mouse)

Signaling Pathways	Product ref	Informations
Cytokines	CT1M1	List infos

Species : Rattus norvegicus (rat)

Signaling Pathways	Product ref	Informations
Cytokines	*******	List In progress...

Species : Sus Scrofa (Pig)

Signaling Pathways	Product ref	Informations
Cytokines	*******	List In progress...

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