The Hypoxia-Inducible Factor 1 HIF-1 pathway is a crucial regulator of cellular responses to low oxygen levels (hypoxia). HIF-1 is a transcription factor composed of two subunits, HIF-1α and HIF-1β, that activate the expression of genes involved in oxygen homeostasis, angiogenesis, metabolism, and cell survival.
In hypoxic conditions, HIF-1α stabilizes and translocates to the nucleus, where it dimerizes with HIF-1β to promote the transcription of target genes.
AnyGenes® offers state-of-the-art qPCR arrays designed to analyze the HIF-1 pathway at the molecular level. Our advanced tools empower researchers to:
Discover our advanced qPCR arrays for HIF-1 Signaling Pathway research.
The oncogenic and tumor suppressive activity of HIF in tumor and stromal cells.
The HIF-1 pathway orchestrates a wide range of biological processes crucial for cellular adaptation to hypoxia:
The dysregulation of the HIF 1 pathway is implicated in a range of pathological conditions:
Our qPCR arrays provide precise and reproducible data for studying the HIF 1 pathway, helping researchers to:
Explore the complexities of the HIF 1 pathway with AnyGenes® qPCR solutions. Our tools are tailored to advance your research with accuracy and efficiency, enabling groundbreaking discoveries in hypoxia-related biology.
Given its central role in tumor biology, the HIF-1 pathway has emerged as a promising target for cancer therapy. Several inhibitors targeting HIF-1α are under investigation:
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