HIPPO SIGNALING PATHWAY

Hippo signaling pathway components are structurally and functionally conserved and are notable for their role in controlling organ size, in addition to their implication in diverse functions including development, tissue homeostasis, wound healing and regeneration, immunity, epithelial homeostasis, tissue regeneration, immune modulation, cell differentiation, regulation of autophagy, tumor suppression. ^(1,2,3,5).

Schematics diagram of the Hippo pathway ⁽⁵⁾ .

THE SIGNALING PATHWAYS AND DISEASES

Dysregulation of the Hippo pathway contributes to a number of human diseases, such as cancer, autoimmunity, developmental anomalies and liver fibrosis … ^(1,2,3,4).

(1) Wu Z, Guan KL. Hippo Signaling in Embryogenesis and Development. Trends Biochem Sci. (2021);46(1):51-63.

(2) Dey A, Varelas X, Guan KL. Targeting the Hippo pathway in cancer, fibrosis, wound healing and regenerative medicine. Nat Rev Drug Discov. (2020);19(7):480-494.

(3) Zheng Y, Pan D. The Hippo Signaling Pathway in Development and Disease. Dev Cell. (2019);50(3):264-282.

(4) Driskill JH, Pan D. The Hippo Pathway in Liver Homeostasis and Pathophysiology. Annu Rev Pathol. (2021);16:299-322.

(5) Wang D et al. Emerging role of the Hippo pathway in autophagy. Cell Death Dis. (2020);11(10):880.