WNT/β-CATENIN SIGNALING PATHWAY

The Wnt beta Catenin signaling pathway is a highly conserved mechanism critical for regulating cell proliferation, differentiation, migration, and survival. This pathway plays a central role in embryonic development, tissue regeneration, and maintaining homeostasis. Dysregulation of Wnt/β-Catenin signaling is linked to numerous diseases, including cancer, fibrosis, and metabolic disorders.

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Discover our advanced qPCR arrays for Wnt/β Catenin Signaling research.

Wnt/β-Catenin Signaling: The Culprit in Pancreatic Carcinogenesis and Therapeutic Resistance.

KEY MECHANISMS OF WNT/β-CATENIN SIGNALING

Wnt signaling is activated when Wnt ligands bind to Frizzled receptors on the cell surface, stabilizing β-catenin. This allows β-catenin to accumulate in the cytoplasm and translocate into the nucleus, where it activates the transcription of target genes.

Core Components Include:

Wnt Ligands: Trigger signaling cascades by binding to receptors.
Frizzled Receptors: Cell surface receptors that mediate Wnt signaling.
β-Catenin: A key mediator that regulates gene transcription.
Destruction Complex: A protein complex that degrades β-catenin in the absence of Wnt signals.

WNT beta CATENIN PATHWAY IN DISEASES

Imbalances in Wnt signaling contribute to:

Cancer: Aberrant activation leads to uncontrolled cell proliferation in cancers like colorectal and breast cancer.
Fibrosis: Overactivation contributes to tissue scarring in the liver, lungs, and kidneys.
Bone Disorders: Impacts bone formation and resorption, influencing conditions like osteoporosis.
Neurological Diseases: Implicated in disorders like Alzheimer's due to its role in neurogenesis and synaptic function.
Obesity and diabetes.

DYNAMIC REGULATION OF WNT SIGNALING

The Wnt beta Catenin signaling cascade is tightly regulated by feedback mechanisms.

In the “Off” State: The destruction complex, composed of APC, Axin, GSK-3β, and CK1, targets β-catenin for degradation, preventing gene activation.
In the “On” State: Wnt ligand binding inhibits the destruction complex, stabilizing β-catenin, which then moves to the nucleus to regulate gene expression.

This fine-tuned balance ensures proper cellular responses to environmental cues.

CROSSTALK BETWEEN WNT AND OTHER SIGNALING PATHWAYS

The Wnt/β-Catenin signaling pathway does not operate in isolation; it interacts with various other pathways to orchestrate complex cellular responses. This crosstalk is crucial for maintaining cellular balance and responding to environmental changes.

Wnt and Notch Pathway: These pathways work together to regulate stem cell behavior and tissue regeneration. While Wnt promotes proliferation, Notch controls differentiation, ensuring proper development and repair.
Wnt and TGF-β/Smad Pathway: This interaction is vital in fibrosis and cancer progression. TGF-β signaling enhances Wnt/β-Catenin activity, driving excessive extracellular matrix deposition in fibrotic tissues.
Wnt and PI3K-Akt Pathway: Involved in promoting cell survival, this crosstalk enhances resistance to stress and apoptosis, particularly in cancer cells.
Wnt and Hedgehog Pathway: These pathways cooperate in embryonic development, particularly in organ formation like the brain and heart. Dysregulation can lead to developmental disorders and cancers.

Wnt-beta-Catenin-Signaling-pathway-in-diseases

WNT Signaling in Disease.

(1) Haseeb M et al. Wnt Signaling in the Regulation of Immune Cell and Cancer Therapeutics. Cells. (2019)3;8(11).

(2) Lecarpentier Y et al. Multiple Targets of the Canonical WNT/β-Catenin Signaling in Cancers. Front Oncol. (2019)18;9:1248..

(3) Zhong Z et Virshup DM. Wnt signaling and drug resistance in cancer. Mol Pharmacol. (2019)1.

(4) Mo Y et al. The role of Wnt signaling pathway in tumor metabolic reprogramming. J Cancer. (2019)9;10(16):3789-3797.

(5) Ram Makena M et al. Wnt/β-Catenin Signaling: The Culprit in Pancreatic Carcinogenesis and Therapeutic Resistance. Int J Mol Sci. (2019)30;20(17).

(6) Ng LF et al. WNT Signaling in Disease. Cells. (2019)3;8(8).

WNT beta CATENIN SIGNALING PATHWAY BIOMARKER LIST

Customize your own signaling pathways (SignArrays®) with the factors of your choice!
Simply download and complete our Personalized SignArrays® information file and send it at [email protected] to get started on your project.

You can check the biomarker list included in this pathway, see below:

Species : Homo sapiens (human)

Signaling Pathways	Product ref	Informations
Wntβ-catenin Signaling Pathway	WNTB1H1	List infos

Species : Mus musculus (mouse)

Signaling Pathways	Product ref	Informations
Wntβ-catenin Signaling Pathway	WNTB1M1	List infos

Species : Rattus norvegicus (rat)

Signaling Pathways	Product ref	Informations
Wntβ-catenin Signaling Pathway	*******	List In progress...

Species : Sus Scrofa (Pig)

Signaling Pathways	Product ref	Informations
Wntβ-catenin Signaling Pathway	*******	List In progress...

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