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AnyGenes

WHAT IS THE TGF BETA SIGNALING PATHWAY?

The Transforming Growth Factor-beta TGF beta signaling pathway (TGF-β) plays a critical role in regulating cellular growth, differentiation, immune response, and tissue repair. This pathway is vital for maintaining homeostasis and is implicated in various diseases, including cancer, fibrosis, and autoimmune disorders.

Why Choose AnyGenes® for TGF-β Signaling Research?

At AnyGenes®, we provide state-of-the-art qPCR arrays designed specifically for comprehensive analysis of the TGF-β signaling pathway. Our innovative solutions empower researchers to:

  • Investigate key components such as TGF-β ligands, receptors, and SMAD transcription factors.
  • Analyze downstream targets involved in epithelial-to-mesenchymal transition (EMT) and fibrosis.
  • Study interactions with other signaling pathways, including Wnt, Notch, and MAPK.

Our qPCR arrays offer unmatched precision and reproducibility, enabling detailed insights into the TGF-β pathway's role in health and disease.

AnyGenes® TGF-β Signaling Pathway Array for Gene Expression Analysis.

Discover our advanced qPCR arrays for TGF beta Signaling Pathway research.

TGF-beta-signaling- pathways

Overview of the TGFβ family pathways.

KEY COMPONENTS OF THE TGF beta SIGNALING PATHWAY

  • Ligands: The TGF-β superfamily includes TGF-β1, TGF-β2, TGF-β3, activins, and bone morphogenetic proteins (BMPs).
  • Receptors: Type I and Type II receptors, which are serine/threonine kinases, mediate signal transduction.
  • SMAD Proteins: Intracellular mediators like SMAD2, SMAD3, and SMAD4 regulate transcriptional responses.
  • Regulators: Inhibitory SMADs (SMAD6, SMAD7) and co-factors modulate pathway activity.

TGF beta FUNCTION

Transforming Growth Factor Beta (TGF-β) is a key cytokine involved in regulating cell growth, differentiation, apoptosis, and immune responses. It:

  1. Regulates Cell Growth: Inhibits cell proliferation in many cell types to prevent tumor formation.
  2. Promotes Cell Differentiation: Drives the development of specialized cells like fibroblasts and smooth muscle cells.
  3. Stimulates ECM Production: Enhances the synthesis of collagen and fibronectin, crucial for tissue repair.
  4. Modulates Immunity: Suppresses immune responses to maintain tolerance and prevent autoimmune diseases.
  5. Affects Fibrosis: Plays a role in tissue repair, but excessive signaling can lead to fibrosis.
  6. Influences Tumorigenesis: Acts as a tumor suppressor early on, but may promote cancer progression later.

Dysregulation of TGF-β signaling is linked to diseases like cancer, fibrosis, and immune disorders.

CLINICAL RELEVANCE OF TGF-beta SIGNALING

The TGF-β pathway is implicated in diverse biological and pathological processes:

  • Cancer: Promotes tumor progression, invasion, and metastasis in advanced stages, but TGF-β functions as a tumor suppressor in early stages by inhibiting cell proliferation and inducing apoptosis.
  • Fibrosis: Drives extracellular matrix production and tissue scarring in organs like the liver, lungs, and kidneys.
  • Immune Regulation: Modulates immune responses and maintains tolerance.

Studying this pathway is critical for developing novel therapeutic strategies targeting fibrosis, cancer, and autoimmune diseases.

TGF beta INHIBITORS IN CLINICAL RESEARCH

Because of its role in fibrosis and cancer progression, TGF-β has become a target for drug development:

  • TGF-β Inhibitors: Researchers are exploring TGF-β inhibitors as potential treatments for fibrotic diseases, cancer, and autoimmune disorders.
  • Therapeutic Strategies: Inhibiting TGF-β signaling could help prevent or reverse fibrosis and inhibit cancer metastasis.
(1) Suriyamurthy S et al. Epigenetic Reprogramming of TGF-β Signaling in Breast Cancer. Cancers (Basel). (2019) 24;11(5).
(2) Chen J et al. Immunomodulatory TGF-β Signaling in Hepatocellular Carcinoma. Trends Mol Med. (2019).
(3) Chen Y et al. Transforming growth factor β signaling pathway: A promising therapeutic target for cancer. J Cell Physiol. (2019).
(4) Batlle E et Massagué J. Transforming Growth Factor-β Signaling in Immunity and Cancer. Immunity. (2019) 16;50(4):924-940.
(5) Pellatt AJ et al.The TGFβ-signaling pathway and colorectal cancer: associations between dysregulated genes and miRNAs. J Transl Med. (2018);16(1):191.
(6) Papoutsoglou P et al. Transforming Growth Factor-Beta (TGFβ) Signaling Pathway in Cholangiocarcinoma.Cells. (2019)23;8(9).
(7) Neuzillet C et al. Targeting the TGFβ pathway for cancer therapy. PharmacolTher. (2015);147:22-31.
(8) Bellomo C et al. Transforming growth factor β as regulator of cancer stemness and metastasis. Br J Cancer. 2016 Sep 27;115(7):761-9 

TGF beta SIGNALING PATHWAY BIOMARKER LIST

Customize your own signaling pathways (SignArrays®) with the factors of your choice!
Simply download and complete our Personalized SignArrays® information file and send it at [email protected] to get started on your project.

You can check the biomarker list included in this pathway, see below:

Species : Homo sapiens (human)

Human TGFβ Signaling Pathway

Signaling PathwaysProduct refInformations

TGFβ Signaling Pathway

TGFB1H1

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Species : Mus musculus (mouse)

Mouse TGFβ Signaling Pathway

Signaling PathwaysProduct refInformations

TGFβ Signaling Pathway

TGFB1M1

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Species : Rattus norvegicus (rat)

Rat TGFβ Signaling Pathway

Signaling PathwaysProduct refInformations

TGFβ Signaling Pathway

TGFB1R1

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Species : Sus Scrofa (Pig)

Pig TGFβ Signaling Pathway

Signaling PathwaysProduct refInformations

TGFβ Signaling Pathway

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List In progress...


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