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Signaling Pathways title  Adipogenesis

Differentiation of preadipocytes to adipocytes (adipogenesis) involves a comprehensive network including transcription factors responsible for expression of key proteins that induce mature adipocyte formation. This process also involves changes in cell morphology, induction of insulin sensitivity and changes in secretory capacity of cells (1).

Signaling Pathways title  Adipogenesis and diseases

Studies on adipogenesis may be important for regulating human and/or animal obesity, which causes several complications such as, type II diabetes, hypertension, and cardiovascular disease (2).
Due to the distribution of adipose tissue in different organs, adipocytes are in close contact with cancer cells in many solid tumors during tumor growth, local invasion or bone metastasis as well as in hematological malignancies (4).

Role of adipocyte as an active facilitator in breast cancer initiation, progression and metastasi (5)

Adipocytes may act as obstacles to therapy (resistance against various breast cancer treatments), and may also be a reservoir for dormant tumor cells during postsurgical autologous fat grafting (5).
In a recent study Sheng and colleagues reported an additional and potentially important mechanism by which adipocytes contribute to chemoresistance. They reported that adipocytes not only sequester the chemotherapeutic drug daunorubicin, but also efficiently metabolize daunorubicin to a therapeutically less effective metabolite, daunorubicinol (3).

Adipose tissue effects in the tumour microenvironment (3)

(1) Moseti D & al. Molecular Regulation of Adipogenesis and Potential Anti-Adipogenic Bioactive Molecules. Int J Mol Sci. (2016) 19;17(1).
(2) Han J & al. Regulation of Adipogenesis Through Differential Modulation of ROS and Kinase Signaling Pathways by 3,4'-Dihydroxyflavone Treatment. J Cell Biochem. (2017);118(5):1065-1077.
(3) Zhang Z1 & Scherer PE. Adipose tissue: The dysfunctional adipocyte - a cancer cell's best friend. Nat Rev Endocrinol. (2018);14(3):132-134.
(4) Duong MN & al. The fat and the bad: Mature adipocytes, key actors in tumor progression and resistance. Oncotarget. (2017).
(5) Choi J & al. Adipocyte biology in breast cancer: From silent bystander to active facilitator. Prog Lipid Res. (2018);(69):11-20.
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