UNDERSTANDING THE HYPOXIA PATHWAY

The hypoxia pathway is a fundamental cellular response to low oxygen levels. It regulates crucial processes such as angiogenesis, metabolism, and cell survival.

Hypoxia-inducible factors (HIFs) play a central role by activating genes that help cells adapt to oxygen deficiency. Dysregulation of this pathway is associated with cancer progression, ischemic diseases, and other pathological conditions.

Why Choose AnyGenes® for Hypoxia Pathway Research?

AnyGenes^® provides advanced qPCR arrays tailored for studying the hypoxia pathway. Our solutions empower researchers to:

Investigate key regulators like HIF-1α, VEGF, and EPO.
Analyze changes in gene expression during oxygen scarcity.
Explore the interactions between oxygen regulation and other signaling pathways, such as PI3K/Akt and mTOR.

Our qPCR arrays are designed for precision, reproducibility, and reliability, enabling you to uncover novel insights into the molecular mechanisms of oxygen deprivation.

Discover our advanced qPCR arrays for Hypoxia Pathway research.

Hypoxia-inducible factor (HIF) regulation during normoxia and hypoxia.

KEY MECHANISMS IN THE HYPOXIA PATHWAY

HIF Activation: Under low oxygen conditions, HIF-1α stabilizes and dimerizes with HIF-1β, activating target genes involved in angiogenesis, metabolism, and survival.
Angiogenesis Regulation: VEGF and other factors are upregulated to promote the formation of new blood vessels and restore oxygen supply.
Metabolic Adaptation: Oxygen scarcity triggers a metabolic shift to glycolysis to sustain energy production.
Crosstalk with Other Pathways: Interactions with signaling pathways like PI3K/Akt and Wnt highlight the complexity of cellular responses to oxygen reduction.

BIOLOGICAL FUNCTIONS OF THE OXYGEN SIGNALING PATHWAY

Oxygen regulation is vital for:

Oxygen Homeostasis: Regulating cellular adaptation to low oxygen levels.
Angiogenesis: Promoting blood vessel formation to restore oxygen supply.
Metabolic Reprogramming: Supporting cell survival during hypoxic stress.
Tumor Progression: Enhancing cancer cell survival, angiogenesis, and metastasis.
Ischemic Tissue Repair: Facilitating recovery in conditions such as stroke and myocardial infarction.

DISEASES LINKED TO OXYGEN DEFICIENCY SIGNALING

Dysfunctions in oxygen-sensing mechanisms are implicated in:

Cancer: HIF-driven responses support tumor growth, angiogenesis, and resistance to therapy.
Ischemic Disorders: Oxygen deprivation contributes to tissue injury and repair in strokes, heart attacks, and other conditions.
Chronic Respiratory Diseases: Persistent low oxygen levels alter pulmonary function and tissue remodeling.
Metabolic Diseases: Oxygen scarcity influences insulin resistance and metabolic changes in obesity and diabetes.

TYPES OF HYPOXIA

Hypoxic Conditions: Reduced oxygen availability in the air or lungs (e.g., high altitude).
Anemic Oxygen Deficiency: Insufficient oxygen transport due to low hemoglobin or red blood cells.
Ischemic Conditions: Restricted blood flow, preventing oxygen delivery to tissues.
Histotoxic Oxygen Impairment: Impaired cellular oxygen utilization due to toxins (e.g., cyanide poisoning).

Lee JW et al. Hypoxia signaling in human diseases and therapeutic targets. Exp Mol Med. (2019);51(6):1-13.
Tirpe AA et al. Hypoxia: Overview on Hypoxia-Mediated Mechanisms with a Focus on the Role of HIF Genes. Int J Mol Sci. (2019);20(24):6140.
Yuen VW, Wong CC. Hypoxia-inducible factors and innate immunity in liver cancer.J Clin Invest. (2020);130(10):5052-5062.
Yeo EJ. Hypoxia and aging. Exp Mol Med. (2019);51(6):1-15.
Serebrovska ZO et al. Hypoxia, HIF-1α, and COVID-19: from pathogenic factors to potential therapeutic targets. Acta Pharmacol Sin. (2020);41(12):1539-1546.

HYPOXIA SIGNALING PATHWAY BIOMARKER LIST

Customize your own signaling pathways (SignArrays^®) with the factors of your choice!
Simply download and complete our Personalized SignArrays^® information file and send it at [email protected] to get started on your project.

You can check the biomarker list included in this pathway, see below:

Species : Homo sapiens (human)

Human signaling pathways

Signaling Pathways	Product ref	Informations
Hypoxia	HY1H1	List infos
Hypoxia	HY2H1	List infos

Species : Mus musculus (mouse)

Mouse signaling pathways

Signaling Pathways	Product ref	Informations
Hypoxia	HY1M1	List infos
Hypoxia	HY2M1	List infos

Species : Rattus norvegicus (rat)

Rat signaling pathways

Signaling Pathways	Product ref	Informations
Hypoxia	*******	List In progress...

Species : Sus Scrofa (Pig)

Pig Hypoxia

Signaling Pathways	Product ref	Informations
Hypoxia	*******	List In progress...

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