UNDERSTANDING THE HYPOXIA PATHWAY

The hypoxia pathway is a fundamental cellular response to low oxygen levels. It regulates crucial processes such as angiogenesis, metabolism, and cell survival. Hypoxia-inducible factors (HIFs) play a central role by activating genes that help cells adapt to oxygen deficiency. Dysregulation of this pathway is associated with cancer progression, ischemic diseases, and other pathological conditions.

Why Choose AnyGenes® for Hypoxia Pathway Research?

AnyGenes® provides advanced qPCR arrays tailored for studying the hypoxia pathway. Our solutions empower researchers to:

Investigate key regulators like HIF-1α, VEGF, and EPO.
Analyze changes in gene expression during oxygen scarcity.
Explore the interactions between oxygen regulation and other signaling pathways, such as PI3K/Akt and mTOR.

Our qPCR arrays are designed for precision, reproducibility, and reliability, enabling you to uncover novel insights into the molecular mechanisms of oxygen deprivation.

Explore AnyGenes® Hypoxia Pathway qPCR Array for precise gene expression analysis under low oxygen conditions.

Discover our advanced qPCR arrays for Hypoxia Pathway research.

Hypoxia-inducible factor (HIF) regulation during normoxia and hypoxia.

KEY MECHANISMS IN THE HYPOXIA PATHWAY

HIF Activation: Under low oxygen conditions, HIF-1α stabilizes and dimerizes with HIF-1β, activating target genes involved in angiogenesis, metabolism, and survival.
Angiogenesis Regulation: VEGF and other factors are upregulated to promote the formation of new blood vessels and restore oxygen supply.
Metabolic Adaptation: Oxygen scarcity triggers a metabolic shift to glycolysis to sustain energy production.
Crosstalk with Other Pathways: Interactions with signaling pathways like PI3K/Akt and Wnt highlight the complexity of cellular responses to oxygen reduction.

BIOLOGICAL FUNCTIONS OF THE OXYGEN SIGNALING PATHWAY

Oxygen regulation is vital for:

Oxygen Homeostasis: Regulating cellular adaptation to low oxygen levels.
Angiogenesis: Promoting blood vessel formation to restore oxygen supply.
Metabolic Reprogramming: Supporting cell survival during hypoxic stress.
Tumor Progression: Enhancing cancer cell survival, angiogenesis, and metastasis.
Ischemic Tissue Repair: Facilitating recovery in conditions such as stroke and myocardial infarction.

DISEASES LINKED TO OXYGEN DEFICIENCY SIGNALING

Dysfunctions in oxygen-sensing mechanisms are implicated in:

Cancer: HIF-driven responses support tumor growth, angiogenesis, and resistance to therapy.
Ischemic Disorders: Oxygen deprivation contributes to tissue injury and repair in strokes, heart attacks, and other conditions.
Chronic Respiratory Diseases: Persistent low oxygen levels alter pulmonary function and tissue remodeling.
Metabolic Diseases: Oxygen scarcity influences insulin resistance and metabolic changes in obesity and diabetes.

TYPES OF HYPOXIA

Hypoxic Conditions: Reduced oxygen availability in the air or lungs (e.g., high altitude).
Anemic Oxygen Deficiency: Insufficient oxygen transport due to low hemoglobin or red blood cells.
Ischemic Conditions: Restricted blood flow, preventing oxygen delivery to tissues.
Histotoxic Oxygen Impairment: Impaired cellular oxygen utilization due to toxins (e.g., cyanide poisoning).

(1) Lee JW et al. Hypoxia signaling in human diseases and therapeutic targets. Exp Mol Med. (2019);51(6):1-13.

(2) Tirpe AA et al. Hypoxia: Overview on Hypoxia-Mediated Mechanisms with a Focus on the Role of HIF Genes. Int J Mol Sci. (2019);20(24):6140.

(3) Yuen VW, Wong CC. Hypoxia-inducible factors and innate immunity in liver cancer.J Clin Invest. (2020);130(10):5052-5062.

(4) Yeo EJ. Hypoxia and aging. Exp Mol Med. (2019);51(6):1-15.

(5) Serebrovska ZO et al. Hypoxia, HIF-1α, and COVID-19: from pathogenic factors to potential therapeutic targets. Acta Pharmacol Sin. (2020);41(12):1539-1546.

HYPOXIA SIGNALING PATHWAY BIOMARKER LIST

Customize your own signaling pathways (SignArrays®) with the factors of your choice!
Simply download and complete our Personalized SignArrays® information file and send it at [email protected] to get started on your project.

You can check the biomarker list included in this pathway, see below:

Species : Homo sapiens (human)

Signaling Pathways	Product ref	Informations
Hypoxia	HY1H1	List infos
Hypoxia	HY2H1	List infos

Species : Mus musculus (mouse)

Signaling Pathways	Product ref	Informations
Hypoxia	HY1M1	List infos
Hypoxia	HY2M1	List infos

Species : Rattus norvegicus (rat)

Signaling Pathways	Product ref	Informations
Hypoxia	*******	List In progress...

Species : Sus Scrofa (Pig)

Signaling Pathways	Product ref	Informations
Hypoxia	*******	List In progress...

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