HYPOXIA

Hypoxia refers to a condition in which oxygen is limited. It is mainly related to pathological situations, but it can also be a part of normal physiology. Hypoxic responses are controlled by hypoxia-inducible factors (HIFs) ^(1,4).

Hypoxia-inducible factor (HIF) regulation during normoxia and hypoxia ⁽¹⁾ .

DEFICIENCY OF OXYGEN AND DISEASES

An adequate concentration of oxygen is required by eukaryotic cells to maintain a variety of biological activities and ensure survival. Oxygen starvation represents a frequent player in a number of malignancies, contributing to the development of the neoplastic disease such as liver cancer, and innate immunity, aging, COVID-19, heart disease, pulmonary disease, kidney disease…^(1,2,3,4,5)

(1) Lee JW et al. Hypoxia signaling in human diseases and therapeutic targets. Exp Mol Med. (2019);51(6):1-13.

(2) Tirpe AA et al. Hypoxia: Overview on Hypoxia-Mediated Mechanisms with a Focus on the Role of HIF Genes. Int J Mol Sci. (2019);20(24):6140.

(3) Yuen VW, Wong CC. Hypoxia-inducible factors and innate immunity in liver cancer.J Clin Invest. (2020);130(10):5052-5062.

(4) Yeo EJ. Hypoxia and aging. Exp Mol Med. (2019);51(6):1-15.

(5) Serebrovska ZO et al. Hypoxia, HIF-1α, and COVID-19: from pathogenic factors to potential therapeutic targets. Acta Pharmacol Sin. (2020);41(12):1539-1546.

HYPOXIA SIGNALING PATHWAY BIOMARKER LIST

You can custom your own SignArrays® with the genes of interest of your choice, according to your project, you just have to download and complete our Personalized SignArrays® information file and send it at [email protected]

You can check the biomarker list included in this pathway, see below:

Species : Homo sapiens (human)

Human Hypoxia

Signaling Pathways	Product ref	Informations
Hypoxia	HY1H1	List infos
Hypoxia	HY2H1	List infos

Species : Mus musculus (mouse)

Mouse Hypoxia

Signaling Pathways	Product ref	Informations
Hypoxia	HY1M1	List infos
Hypoxia	HY2M1	List infos

Species : Rattus norvegicus (rat)

Rat Hypoxia

Signaling Pathways	Product ref	Informations
Hypoxia	*******	List In progress...

Species : Sus Scrofa (Pig)

Pig Hypoxia

Signaling Pathways	Product ref	Informations
Hypoxia	*******	List In progress...

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