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      • Adipogenesis
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  • Signaling Pathways (SignArrays® System)

Signaling Pathways title  Real-time PCR arrays for your signaling pathways analysis

» More than 500 cell signaling pathways ready to use in cancer, other diseases and normal cells

AnyGenes® helps you to analyse your favorite signaling pathways (SignArrays®) in less than 2 hours at very competitive prices.

Since more than 15 years, AnyGenes® team is proud to offer you a large panel of signaling pathways or gene expression assays that you can easily custom to your project needs. Our SignArrays® are widely used by scientific community and are mentioned by high impact factor scientific publications, with positive feedbacks for the efficiency of our products. Indeed, AnyGenes® SignArrays® help in reducing time to get reliable qPCR array results, and accelerating publications rate.

AnyGenes® has developed and optimized the SignArrays® system with its range of Perfect Master Mix SYBR® Green to guarantee highly specific, reliable and reproducible qPCR arrays results for signaling pathways analysis, even with small amounts of precious samples like FFPE or LCM samples.

Click on the picture below to select your favorite SignArrays® among our large collection of signaling and pathological pathways:

qPCR Array and PCR Array Select your favorite Signaling Pathways (qPCR 96 or 384 plates) compatible with all qPCR instruments. SignPath Neuro AutoImmune Mental Cancer Other Pharmaco Personal

All our signaling pathways are validated at the experimental level on a large collection of tissues and cell lines on our high-throughput molecular platform, thanks to stringent and strong quality control criteria to guarantee you the best results.

We propose you a whole range of SignArrays® at the 96 or 384 plate format, compatible with most of all qPCR instruments on the market.

Each SignArray® 96 allows to analyse 84 genes of interest, specific to a signaling or pathological pathway with 8 reference genes necessary to the robust normalisation step of your qPCR data and 4 quality controls.

Available for many species : Homo sapiens, Mus musculus, Rattus norvegicus, Sus scrofa and more on demand!

qPCR Array and PCR Array Example of Cytokines SignArray plate layout: 84 genes of interest, 8 house-keeping genes and 4 quality controls.
qPCR Array and PCR Array AnyGenes® monitors the reproducibility of their SignArrays with strict quality controls (example with 2 Human Apoptosis SignArrays performed from the same sample).

Signaling Pathways title  Our qPCR signaling pathways (SignArrays®) characteristics :

  • ALL IN ONE SOLUTION
  •  STRICT INTRON FLANKING
    PRIMER DESIGN
  •  A FAST AND EASY PROTOCOL
  •  APPLICATIONS

Specific signaling pathway (96 or 384 qPCR well plates)

+ Sensitive and highly accurate qPCR reagents
(Perfect Master Mix SYBR® Green & EvaGreen)

+ Free data analysis software

+ Compatible with all qPCR instruments
qPCR Array and PCR Array All-in-one solution SignArrays system to explore your favorite Signaling Pathways (SignArrays + qPCR reagents + Free data analysis software).
qPCR Array and PCR Array All-in-one solution SignArrays system to explore your favorite Signaling Pathways (SignArrays + qPCR reagents + Free data analysis software).

qPCR Array and PCR Array A free data analysis software is available to help you to analyse your qPCR SignArrays results.
qPCR Array and PCR Array A free data analysis software is available to help you to analyse your qPCR SignArrays results.

- In order to guarantee sensitive, specific and accurate results, every primer set is designed with highly stringent criteria and validated at the experimental level on a large collection of tissues and cell lines on our high-throughput molecular platform thanks to strict experimental quality controls.

- We offer you very high quality primers.

- With a primer design on 2 exons (whenever possible, according to the genes of interest) to guarantee high specificity in qPCR and avoid any contaminating gDNA amplification.

qPCR Array and PCR Array Strict intron flanking primer design to guarantee the high specificity of our qPCR primers.
qPCR Array and PCR Array Strict intron spanning primer design to guarantee the high specificity of our qPCR primers.

Your signaling pathway SignArrays® results in less than 2 hours !

AnyGenes® has standardised its signaling pathways SignArrays® protocols to let you perform your qPCR analysis in the easiest way.

You just have to prepare your qPCR mixes with the Perfect Master Mix SYBR® Green and your cDNA samples, and dispense !
qPCR Array and PCR Array An optimised protocol to ensure you SignArrays Signaling Pathways results in less than 2 hours !
qPCR Array and PCR Array An optimised protocol to ensure you SignArrays Signaling Pathways results in less than 2 hours !

Your signaling pathways SignArrays® are perfect for many applications:


Gene expression profiling
Drug development
Biomarker signature identification
Validation of microarray results

Another application in mind according to your projects ? Please contact us at [email protected]
qPCR Array and PCR Array SignArrays Signaling Pathways can be used for many applications : from gene expression profiling to biomarker identification and validation.
qPCR Array and PCR Array SignArrays Signaling Pathways can be used for many applications : from gene expression profiling to biomarker identification and validation.

Signaling Pathways title  Select your signaling pathways below :

Signaling Pathways

  • Adipogenesis

  • AMPK Signaling Pathway

  • Angiogenesis

    Angiogenesis, the formation of blood vessels, occurs in a coordinated series of steps, which can be divided into a destabilization, a proliferation, and a maturation phase.

    Extensive studies have revealed a variety factors involved in neoangiogenesis, the main protagonists are: Vascular endothelial Growth Factor (VEGF), basic Fibroblast Growth Factor (bFGF), various members of the Transforming Growth factor beta (TGFβ) family and hypoxia (Hypoxia-inducible transcription factor, HIF)... Other factors that have angiogenic properties include the angiopoietins, (Ang-1); hepatocyte growth factor (HGF); Platelet-derived growth factor (PDGF-BB); Insulin-like growth factor family (IGF-1, IGF-2) and the Neurotrophins (NGF).

    One of earliest events in angiogenesis is the degradation of the vascular basement membrane and the remodeling of the extracellular matrix (ECM). Several matrix metalloproteinases (MMPs), including MMP-2, -3, and -9 play an important role in this system, and are associated with tumor progression, including invasion, metastasis, growth, migration, and angiogenesis.

    Integrins are the principle adhesion receptors used by endothelial cells to interact with the extracellular environment and are necessary for cell migration, proliferation, and survival.

  • Anti-Apoptotic Factors

  • Antibacterial Response

  • Antifungal Response

  • Antimicrobial Peptides

  • Antiviral Response

  • Apoptosis

    Apoptosis or programmed cell death is a highly regulated process critical for normal development and tissue homeostasis. Aberrant regulation of apoptosis can lead to cancer. Apoptosis is induced from signals inside or outside the cell including radiation, viral infection, growth factors, and hormones. Apoptosis involves signature morphological changes induced by caspases, which are activated upon induction of apoptotic signalling and cleave downstream molecules to facilitate the apoptotic cascade. The induction of apoptosis can occur through two pathways: the intrinsic apoptotic pathway which involves signalling through the mitochondria and the extrinsic apoptotic pathway which is initiated through activation of cell surface death receptors. Apoptotic signalling through the intrinsic pathway primarily involves activation of the proapoptotic Bcl-2 family members Bax and Bak, which facilitate release of cytochome C from the mitochondria and subsequent caspase-9 cleavage or activation. The activated caspase-9 will finally cleave or activate the downstream effector caspases such as caspase-3 and -7, leading to apoptosis.This pathway is negatively regulated by several antiapoptotic Bcl-2 family members such as Bcl-2 and Bcl-XL. Apoptotic signalling through the extrinsic pathway is initiated by ligand binding to death receptors or by induction of trimerization of the receptors. The death receptors belong to the tumor necrosis factor (TNF) receptor superfamily, which includes Fas, TNFR1, DR3, DR4 (TRAIL-R1),DR5(TRAIL-R2),and DR6.

  • Autophagy

    Autophagy is a lysosomal catabolic process that leads to sequestration and degradation of intracellular material. It functions at basal level in every cell and contributes to maintain cellular homeostasis, clearance of damaged organelles and adaptation to environmental stresses.
    In contrast, if the autophagy activity is too high, it may promote Apoptosis.
    Autophagy is involved in preventing certain types of disease: however dysfunction of autophagy has been implicated in multiple human diseases including cancer, neurodegeneration, and pathogen infection.
    Analyses of molecular mechanism have provided huge advances toward understanding the molecular basis of autophagy. The signaling pathways that are involved in mammalian autophagy imply specific genes or proteins called Atg, in particular Atg5 which exhibits a dual function by modelling both autophagy and apoptosis like Bcl-2. It is also well known that mTOR (target of rapamycin) an evolutionarily-conserved protein kinase, plays a crucial role as a regulator of autophagy.

  • Cardiomyocytes Signaling Pathway

  • Caspase Activation

  • Cell Cycle

  • Cell Cycle & Cancer

  • Cell Invasion

  • Cell Motility

  • Cell Polarity

  • Cell Proliferation

  • Cell Surface Markers

  • Cellular Senescence

  • Chemokines & Receptors

  • Cytokines

  • Dendritic Cells

  • EGF-PDGF Signaling Pathway

  • Endothelial To Mesenchymal Transition

  • Epigenetic Regulation

  • Epithelial To Mesenchymal Transition

  • ERBB Signaling Pathway

  • ERK Signaling Pathway

  • Estrogen Receptor & Breast Cancer

  • Fibrosis

  • G1-S Regulators

  • G2-M Regulators

  • Growth Factors

  • Hematopoietic Stem Cells

  • HIF-1 Signaling Pathway

  • HIPPO Signaling Pathway

  • Human Leukocyte Antigen

  • Human Mitochondria

  • Hypoxia

  • IL6-STAT3 Signaling Pathway

  • Immune Checkpoints

  • Immune Tolerance

  • Inflammasome Signaling Pathway

  • Inflammation

  • Inflammation & Autoimmunity

  • Innate & Adaptive Immune Response

  • Insulin Resistance

  • Integrated Stress Response

  • Interferons & Immune System

  • JAK-STAT Signaling Pathway

  • JNK Signaling Pathway

  • Langerhans Cell Histiocytosis

  • Long Non Coding RNA

  • Lymphangiogenesis

  • MAP Kinase (MAPK) Signaling Pathway

  • Mineralization of the dentin matrix

  • mTOR Signaling Pathway

  • Necrosis

  • NFKB Signaling Pathway

  • Nitric Oxide Signaling Pathway

  • Notch Signaling Pathway

  • Oncogenes

  • Oncogenes & Tumor Suppressor

  • Osteogenesis

  • Oxidative Stress

  • Oxidative Stress & Antioxidant Defense

  • PI3K-AKT Signaling Pathway

  • Pluripotent Embryonic Stem Cells

  • Proteases

  • Protein Kinases

  • Proteo-Glycosaminoglycans Biosynthesis Genes

  • RAS-MAPK Signaling Pathway

  • Reference Genes

  • Signal Transduction

  • Stress & Toxicity Signaling Pathway

  • Surface Antigens (CD)

  • T & B Lymphocyte Activation

  • T helper 17 (Th17) & Cytokines Signaling Pathway

  • T Helper Cells Signaling Pathway

  • TGFβ Signaling Pathway

  • TNF Signaling Pathway

  • Toll-Like Receptors

  • Toxicity & Developmental Growth Factors

  • Transcription Factors

  • Transplant Rejection

  • Tumor Microenvironment

  • Tumor Supressors

  • Wntβ-catenin Signaling Pathway

  • Wound Healing

Neurodegenerative Diseases Pathways

  • Alzheimer's Disease

  • Amyotrophic Lateral Sclerosis

  • Huntington's Disease

  • Lysosomal Storage Disorder

  • Parkinson's Disease

  • Prion Disease

Autoimmune Diseases Pathways

  • Ankylosing Spondylitis

  • Autism Spectrum Disorders

  • Behçet's Disease

  • Crohn's Disease

  • Juvenile Diabetes (Type 1 Diabetes)

  • Multiple Sclerosis

  • Myasthenia Gravis

  • Psoriasis

  • Rheumatoid Arthritis

  • Systemic Lupus Erythematosus

  • Thyroiditis

  • Vitiligo

Mental Disorders Pathways

  • Anxiety Disorder

  • Bipolar Disorder

  • Major Depressive Disorder

  • Schizophrenia Disorder

Cancer Diseases

  • Adenocarcinoma

  • Bladder Cancer

  • Brain Cancer

  • Breast Cancer

  • Cervical Cancer

  • Chronic Lymphocytic Leukemia

  • Colorectal Cancer

  • Endometrial Cancer

  • Head & Neck Cancer

  • Liver Cancer

  • Lung Cancer

  • Lymphoma Cancer

  • Melanoma Cancer

  • Myeloma Cancer

  • Ovarian Cancer

  • Pancreatic Cancer

  • Prostate Cancer

  • Renal Cancer

  • Stomach Cancer

  • Thyroid Cancer

Other Pathologies

Pharmacological Pathways

  • Drug & Toxin Response

  • Drug Hepatotoxicity

  • Drug Metabolism

  • Drug Nephrotoxicity

  • Drug Neurotoxicity

  • Drug Resistance

Personalized SignArrays

As AnyGenes® policy is to propose you complete solutions at the closest of your scientific issues, you can custom your own SignArrays® with the genes of interest of your choice, according to your project.

You just have to download and complete our Personalized SignArrays® information file and send it at [email protected]



Standard SignArrays® 96 system prices

Reference type : XXXH1-Y2S
Standard
Number of
SignArrays® 96
Price/unit
(before TAX)
1-4
200 €
5-8
162 €
9-12
144 €
13-24
128 €
25-30
110 €
>30
80 €

* Y: R, A, B or F plate type, according to the qPCR instrument

(see Compatibility file)

*2: according to the number of ordered SignArray®

Customizable SignArrays® 96 system prices

Reference type : PZXH1-Y2S
Customizable
Number of
SignArrays® 96
Price/unit
(before TAX)
1-4
240 €
5-8
194 €
9-12
178 €
13-24
168 €
25-30
160 €
>30
150 €

* Y: R, A, B or F plate type, according to the qPCR instrument

(see Compatibility file)

*2: according to the number of Custom ordered SignArray®

example: PZXH1-R12S for 12 Personalized SignArrays® 96 for Light Cycler® 480 instrument

NB: The minimum order for customizable plates are 4 for less than 32 different genes/plate or 6 for more than 32 different genes/plate.

PMS Reagents associated with SignArrays® 96 prices

Reference type : PMS1-Z2S
PMS Perfect Master Mix SYBR® Green SignArrays® 96*
Number of
SignArrays® 96
Price/unit
(before TAX)
1-4
95 €
5-8
80 €
9-12
72 €
13-24
69 €
>24
64 €

* 10 μl of PMS/reaction for 20 μl final volume

* Z: W, R, LR or F PMS, according to the qPCR instrument (see Compatibility file)

* 2: according to the number of ordered PMS

example: PMS1-W12S for 12 SignArrays® 96 for Light Cycler® 480 instrument

Standard SignArrays® 384 system prices

Reference type : XXXH2-Y2S
Standard
Number of
SignArrays® 384
Price/unit
(before TAX)
1-4
357 €
5-12
286 €
13-24
232 €
>24
200 €

* Y: R, A, B or F plate type, according to the qPCR instrument (cf Compatibility file)

(see Compatibility file)

*2: according to the number of ordered SignArrays®

example: AN1H2-R12S for 12 SignArrays® 384 for Light Cycler® 480 instrument

Customizable SignArrays® 384 system prices

Reference type : PZXH2-Y2S
Customizable
Number of
SignArrays® 384
Price/unit
(before TAX)
1-4
429 €
5-12
343 €
13-24
255 €
>24
230 €

* Y: R, A, B or F plate type, according to the qPCR instrument (cf Compatibility file)

*2: according to the number of Custom ordered SignArray®

example: PZXH2-R12S for 12 Personalized SignArrays® 384 for Light Cycler® 480 instrument

NB: The minimum order for customizable plates are 2 for less than 64 different genes/plate or 6 for more than 64 different genes/plate.

PMS Reagents associated with SignArrays® 384 prices

Reference type : PMS2-Z2S
PMS (Perfect Master Mix SYBR® Green) SignArrays® 384*
Number of
SignArrays® 384
Price/unit
(before TAX)
1-4
189 €
5-12
170 €
13-24
161 €
>24
155 €

* 10 μl of PMS/reaction for 10 μl final volume

* Z: W, R, LR or F PMS, according to the qPCR instrument (cf Compatibility file)

*2: according to the number of ordered PMS

example: PMS2-W12S for 12 SignArrays® 384 for Light Cycler® 480 instrument

** For more information on prices, please contact us at [email protected]


*** These prices are available only in FRANCE, please contact your local distributors of your country

Signaling Pathways
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Average Star Rating is 4.8/5 from the Total 450 Ratings

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