APOPTOSIS PATHWAY, A PROGRAMMED PROCESS OF CELL DEATH

Apoptosis pathway, also named programmed cell death, is a fundament process required for morphogenetic homeostasis during early development and in pathophysiological conditions ⁽¹⁾.

The Apoptosis may be induced by a variety of agents, including low doses of radiation, hypoxia, heat, cytotoxic drugs or more specialized anti-cancer molecules ⁽⁴⁾.

APOPTOSIS PATHWAY AND DISEASES

The apoptosis has been implicated in the pathogenesis of neurodegenerative diseases (Parkinson, Alzheimer, Huntington, and amyotrophic lateral sclerosis), diseases involving the eyes (Glaucoma, Retinal diseases, Age related macular degeneration, Retinitis dystrophies, Dry eye disease…) ⁽²⁾, in cancer ⁽¹⁾
Recent studies show that dysregulation of apoptosis contributes to multidrug resistance ⁽⁴⁾.

Overview of apoptosis signalling pathways and the effects of pro-survival signalling, immune cells and the tumour microenvironment ⁽³⁾ .

(1) Kashyap D et al. Intrinsic and extrinsic pathways of apoptosis: Role in cancer development and prognosis. Adv Protein Chem Struct Biol. (2021);125:73-120.
(2) Abdulhussein D et al. Apoptosis in health and diseases of the eye and brain. Adv Protein Chem Struct Biol. (2021);126:279-306.
(3) Carneiro BA, El-Deiry WS. Targeting apoptosis in cancer therapy. Nat Rev Clin Oncol. (2020);17(7):395-417.
(4) Neophytou CM et al. Apoptosis Deregulation and the Development of Cancer Multi-Drug Resistance. Cancers (Basel). 2021 Aug 28;13(17):4363.

APOPTOSIS SIGNALING PATHWAY BIOMARKER LIST

You can custom your own SignArrays® with the genes of interest of your choice, according to your project, you just have to download and complete our Personalized SignArrays® information file and send it at [email protected]

You can check the biomarker list included in this pathway, see below:

Species : Homo sapiens (human)

Human Signaling Pathways

Signaling Pathways	Product ref	Informations
Apoptosis	AP1H1	List infos
Apoptosis	AP2H1	List infos
Apoptosis	AP3H1	List infos

Species : Mus musculus (mouse)

Mouse Signaling Pathways

Signaling Pathways	Product ref	Informations
Apoptosis	AP1M1	List infos
Apoptosis	AP2M1	List infos
Apoptosis	AP3M1	List infos

Species : Rattus norvegicus (rat)

Rat Signaling Pathways

Signaling Pathways	Product ref	Informations
Apoptosis	AP1R1	List infos
Apoptosis	AP2R1	List infos

Species : Sus Scrofa (Pig)

Pig Signaling Pathways

Signaling Pathways	Product ref	Informations
Apoptosis	*******	List In progress...

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