Inflammasome Signaling Pathway NLRP3, IL1B, CASP1 what else?

NLRP3 inflammasome is a multimeric cytosolic protein complex that assembles in response to cellular perturbations. This assembly leads to the activation of caspase-1, which promotes maturation and release of the inflammatory cytokines interleukin-1β (IL-1β) and IL-18, as well as inflammatory cell death (pyroptosis) ⁽¹⁾.

NLRP3-inflammasome-Mechanism-of-activation.

Mechanism of NLRP3 inflammasome activation ⁽¹⁾ .

Inflammasome and diseases

NLRP3 inflammasome play dual roles in mediating human disease: inflammatory, metabolic (atherosclerosis, nonalcoholic fatty liver disease (NAFLD), gout, type 2 diabetes and obesity induced insulin resistance.), chronic neurodegenerative diseases, and COVID-19... Without ignoring their beneficial role in numerous infectious diseases and some cancers ^(1,3,4).

(1) Sharma BR, Kanneganti TD. NLRP3 inflammasome in cancer and metabolic diseases. Nat Immunol. (2021);22(5):550-559.

(2) Paik S et al. An update on the regulatory mechanisms of NLRP3 inflammasome activation. Cell Mol Immunol. (2021);18(5):1141-1160.

(3) Wang L, Hauenstein AV. The NLRP3 inflammasome: Mechanism of action, role in disease and therapies. Mol Aspects Med. (2020);76:100889.

(4) Zhao N, Di B, Xu LL. The NLRP3 inflammasome and COVID-19: Activation, pathogenesis and therapeutic strategies. Cytokine Growth Factor Rev. (2021);61:2-15.

Species : Homo sapiens (human)

Human Inflammasome Signaling Pathway

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Species : Mus musculus (mouse)

Mouse Inflammasome Signaling Pathway

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Species : Rattus norvegicus (rat)

Rat Inflammasome Signaling Pathway

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Species : Sus Scrofa (Pig)

Pig Inflammasome Signaling Pathway

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