JNK Signaling Pathway, a stress activated protein kinases

The c-Jun N-terminal kinase (JNK) signalling pathway is a conserved response to a wide range of internal and external cellular stress signals, and is involved in a series of vital regulatory mechanisms (such as regulation of apoptosis, growth, proliferation, differentiation, migration, invasion, autophagy, and inflammation, innate and adaptive immune responses) during development and adulthood that are critical to maintain tissue homeostasis ^(1,3,4).

JNK regulation of cell cycle progression, cell adhesion, and cell apoptosis in response to extracellular cytokines such as TNFalpha ⁽⁴⁾ .

JNK signaling pathway and diseases

The JNK pathway has emerged as a key player in regeneration, tumorigenesis (Glioblastoma, Ovarian cancer, Melanoma , Basal and squamous cell carcinoma) and other pathologies (Alzheimer, Parkinson, Huntington), muscle wasting in cancer cachexia, psoriasis and dermal fibrosis...^(2,3,4).

(1) de Los Reyes Corrales T et al. JNK Pathway in CNS Pathologies. Int J Mol Sci. (2021);22(8):3883.

(2) Mulder SE et al. JNK signaling contributes to skeletal muscle wasting and protein turnover in pancreatic cancer cachexia. Cancer Lett. (2020);491:70-77.

(3) Dou Y et al. The Jun N-terminal kinases signaling pathway plays a "seesaw" role in ovarian carcinoma: a molecular aspect. J Ovarian Res. (2019);12(1):99.

(4) Hammouda MB et al. The JNK Signaling Pathway in Inflammatory Skin Disorders and Cancer . Cells. (2020);9(4):857.

Species : Homo sapiens (human)

Human JNK Signaling Pathway

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Species : Mus musculus (mouse)

Mouse JNK Signaling Pathway

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Species : Rattus norvegicus (rat)

Rat JNK Signaling Pathway

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Species : Sus Scrofa (Pig)

Pig JNK Signaling Pathway

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