PI3K-AKT pathway

PI3K-AKT pathway is one of the most important pathways that control many cellular processes including, cell division, autophagy, survival, proliferation, migration, differentiation, angiogenesis, apoptosis, metabolism and protein synthesis ^(1,4).

Upstream activation of the PI3K/Akt signaling pathway ⁽²⁾ .

PI3K-Akt pathway and diseases

The PI3K/Akt signaling pathway controls hallmarks of cancer, including cell survival, metastasis and metabolism ⁽²⁾, in adition to its important role in multidrug resistance in a variety of cancers, such as breast cancer, leukemia, lung cancer, ovarian cancer, hepatocellular carcinoma, and melanoma ⁽³⁾. PI3K/Akt signaling is implicated in numerous pathologies like skin diseases, autoimmune diseases, neurodegenerative diseases and brain tumor metastasis…^(4,5).

(1) Jafari M et al. PI3k/AKT signaling pathway: Erythropoiesis and beyond. J Cell Physiol. (2019);234(3):2373-2385.

(2) He Y et al. Targeting PI3K/Akt signal transduction for cancer therapy. Signal Transduct Target Ther. (2021);6(1):425.

(3)Liu R et al. PI3K/AKT pathway as a key link modulates the multidrug resistance of cancers. Cell Death Dis. (2020);11(9):797.

(4) Teng Y et al. The PI3K/Akt Pathway: Emerging Roles in Skin Homeostasis and a Group of Non-Malignant Skin Disorders. Cells. (2021);10(5):1219.

(5) Chu E et al. Dysregulated phosphoinositide 3-kinase signaling in microglia: shaping chronic neuroinflammation. J Neuroinflammation. (2021);18(1):276.

Species : Homo sapiens (human)

Human Signaling Pathway

Signaling Pathways	Product ref	Informations
PI3K-AKT Signaling Pathway	AKT1H1	List infos

Species : Mus musculus (mouse)

Mouse Signaling Pathway

Signaling Pathways	Product ref	Informations
PI3K-AKT Signaling Pathway	AKT1M1	List infos

Species : Rattus norvegicus (rat)

Rat Signaling Pathway

Signaling Pathways	Product ref	Informations
PI3K-AKT Signaling Pathway	*******	List In progress...

Species : Sus Scrofa (Pig)

Pig Signaling Pathway

Signaling Pathways	Product ref	Informations
PI3K-AKT Signaling Pathway	*******	List In progress...

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