ERBB signaling pathway

The ERBB signaling pathway includes four members of the ErbB family of receptor tyrosine kinases (RTKs): epidermal growth factor receptor (EGFR) also known as ErbB1 or HER1, ErbB2/HER2, ErbB3/HER3 and ErbB4/HER4, which are expressed in a large number of cell types, including epithelial, endothelial, neuronal and glial, bone, adipose, liver, and cardiovascular cells ^(1,4).

ErbB receptors and their ligands. ErbB2 has no known ligand, while ErbB3 lacks intrinsic kinase activity (indicated by a cross). Following ligand binding, the receptors activate several downstream signaling pathways thereby regulating cell growth, proliferation, and survival. These processes play an important role in development, wound healing and tissue regeneration. EGF, epidermal growth factor; TGFα, transforming growth factor-α; EPG, epigen; AREG, amphiregulin; EREG, epiregulin; BC, betacellulin; HB-EGF, heparin-binding EGF-like growth factor; NRG1-4, neuregulin 1-4; STAT, signal transducer and activator of transcription; MAPK/ERK, mitogen-activated protein kinase/extracellular signal-regulated kinase; PIK3/Akt, phosphoinositide 3-kinase/protein kinase B; PLCγ, phospholipase Cγ ⁽¹⁾ .

EGFR pathway and diseases

Besides its role in many developmental and physiological processes, overactivation of ErbB signaling has been widely described in lung fibrosis, infectious disease and in many forms of cancer, including glioblastoma, lung, breast, ovarian cancer, Head and neck squamous cell carcinoma, invasion, metastasis and resistance to therapy ^(1,2,4).

(1) Schramm F et al. EGFR Signaling in Lung Fibrosis. Cells. (2022);11(6):986.

(2) Palumbo C, et al. Recent findings on the impact of ErbB receptors status on prognosis and therapy of head and neck squamous cell carcinoma. Front Med (Lausanne). (2023);10:1066021.

(3) Jacobi N, et al. ErbB Family Signalling: A Paradigm for Oncogene Addiction and Personalized Oncology. Cancers (Basel). (2017);9(4):33.

(4) Ho J, et al. The Role of ErbB Receptors in Infection. Trends Microbiol. (2017); 25(11): 942–952.

Species : Homo sapiens (human)

Human signaling

Signaling Pathways	Product ref	Informations
ERBB Signaling Pathway	ERBB1H1	List infos

Species : Mus musculus (mouse)

Mouse signaling

Signaling Pathways	Product ref	Informations
ERBB Signaling Pathway	ERBB1M1	List infos

Species : Rattus norvegicus (rat)

Rat signaling

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ERBB Signaling Pathway	*******	List In progress...

Species : Sus Scrofa (Pig)

Pig signaling

Signaling Pathways	Product ref	Informations
ERBB Signaling Pathway	*******	List In progress...

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