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The ERBB signaling pathway includes four members of the ErbB family of receptor tyrosine kinases (RTKs): epidermal growth factor receptor (EGFR) also known as ErbB1 or HER1, ErbB2/HER2, ErbB3/HER3 and ErbB4/HER4, which are expressed in a large number of cell types, including epithelial, endothelial, neuronal and glial, bone, adipose, liver, and cardiovascular cells (1,4).
ErbB-signaling-pathway-receptors and their ligands

  ErbB receptors and their ligands. ErbB2 has no known ligand, while ErbB3 lacks intrinsic kinase activity (indicated by a cross). Following ligand binding, the receptors activate several downstream signaling pathways thereby regulating cell growth, proliferation, and survival. These processes play an important role in development, wound healing and tissue regeneration. EGF, epidermal growth factor; TGFα, transforming growth factor-α; EPG, epigen; AREG, amphiregulin; EREG, epiregulin; BC, betacellulin; HB-EGF, heparin-binding EGF-like growth factor; NRG1-4, neuregulin 1-4; STAT, signal transducer and activator of transcription; MAPK/ERK, mitogen-activated protein kinase/extracellular signal-regulated kinase; PIK3/Akt, phosphoinositide 3-kinase/protein kinase B; PLCγ, phospholipase Cγ (1) .


Besides its role in many developmental and physiological processes, overactivation of ErbB signaling has been widely described in lung fibrosis, infectious disease and in many forms of cancer, including glioblastoma, lung, breast, ovarian cancer, Head and neck squamous cell carcinoma, invasion, metastasis and resistance to therapy (1,2,4).

(1) Schramm F et al. EGFR Signaling in Lung Fibrosis. Cells. (2022);11(6):986.
(2) Palumbo C, et al. Recent findings on the impact of ErbB receptors status on prognosis and therapy of head and neck squamous cell carcinoma. Front Med (Lausanne). (2023);10:1066021.
(3) Jacobi N, et al. ErbB Family Signalling: A Paradigm for Oncogene Addiction and Personalized Oncology. Cancers (Basel). (2017);9(4):33.
(4) Ho J, et al. The Role of ErbB Receptors in Infection. Trends Microbiol. (2017); 25(11): 942–952.


You can custom your own SignArrays® with the genes of interest of your choice, according to your project, you just have to download and complete our Personalized SignArrays® information file and send it at [email protected]

You can check the biomarker list included in this pathway, see below: