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Wound Healing  Wound Healing

Wound healing is a complex process that evolves over weeks to months and involves multiple types of cells (with distinct roles in hemostasis, inflammation, growth, re-epithelialization, and remodeling) and growth factors. However, under some conditions, wound healing can be compromised, leading to prolonged wound healing phases or excessive body responses of to the injury (1,3,4).

The complex interplay of cells, growth factors, and environmental factors involved in wound healing (1)

Wound Healing  Wound healing mechanism

The process of wound healing begins with the host's response to injury by inducing local inflammation, followed by the activation of cell proliferation and tissue remodeling. Each healing phase is governed by the activation and deactivation of genes, resulting from multiples signaling pathways and epigenetic modifications that adjust gene expression (2).
(1) Oliva N, Almquist BD. Spatiotemporal delivery of bioactive molecules for wound healing using stimuli-responsive biomaterials. Adv Drug Deliv Rev. (2020);161-162:22-41.
(2) Nascimento-Filho CHV, et al. Skin wound healing triggers epigenetic modifications of histone H4. J Transl Med. (2020);18(1):138.
(3) Oliveira A, et al. Therapeutic advances in wound healing; J Dermatolog Treat. (2022);33(1):2-22.
(4) Rodrigues M, et al. Wound Healing: A Cellular Perspective. Physiol Rev. (2019);99(1):665-706.
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