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The cell cycle, or the cell division cycle, is the series of events that occur in a cell that push it to divide and produce two new daughter cells.
In eukaryotes, the cell division is composed of four phases including the G1, S, G2, and M phase. Each phase is reliant on the proper completion of the previous cell division phase (1).The perfectly controlled cell division of mammalian cells is essential for cell homeostasis and development. The transition through the different stages is tightly controlled by the cyclins (cyc), their partners Serine/Threonine cyclin-dependent kinases (CDKs), the CDK inhibitors (CKI) and the retinoblastoma family of proteins (pRb) (2,3).
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