CELL SURFACE MARKERS: KEY TOOLS FOR CELL IDENTIFICATION

Cell surface markers (CSM) are proteins, glycoproteins, or carbohydrates present on the membrane of cells. They play crucial roles in cellular identification, signaling, and interactions with the environment. These markers help differentiate various cell type such as immune cells, stem cells, and cancer cells, making them essential in both basic research and clinical application.

AnyGenes provide cutting-edge qPCR arrays designed to facilitate the high-throughput analysis of cell surface markers across different species, including human, mouse, rat and pig. These arrays are highly customizable, offering researchers reliable tools for studying complex cellular processes such as immune response, stem cell differentiation and cancer progression.

AnyGenes SignArrays® for comprehensive analysis of cell surface markers, enabling high-throughput research across human, mouse, rat, and pig species.

Differentiation of T-cell subsets and their respective cell surface marker.

KEY CSM AND THEIR APPLICATIONS

Surface markers are widely used in various research areas. Some notable markers include:

CD3, CD4, CD8: these markers are fundamental in differentiating between various T cell subsets. CD3 is a pan-T cell marker, while CD4 and CD8 differentiate helper T cells and cytotoxic T cells, respectively.
CD19, CD20: these markers are commonly found on B cells, aiding in the study of immune responses and in the diagnosis of B-cell malignancies.
CD34: a marker for hematopoietic stem cells, and it is crucial in research on stem cell therapies and bone marrow transplants.
EpCAM: frequently used in cancer research, EpCAM is an epithelial cell marker involved in studies on tumor progression and circulating tuomor cells (CTCs).

SURFACE MARKERS AND SIGNALING PATHWAYS

CSM play a key role in cellular communication by regulating important signaling pathways that control growth, differentiation and immune response. Markers such as CD4 and CD8 are involved in T-cell activation, while EGFR and PD-1/PD-L1 influence cancer progression and immune evasion.

Signaling pathways like EGFR, NOTCH and Wnt rely on specific surface markers to trigger cellular responses. These pathways are critical for research in cancer, immunology and regenerative medicine.

THE ROLE OF SURFACE MARKERS IN IMMUNOTHERAPY

Surface markers are pivotal in the field of immunotherapy, where they serve as targets for therapeutic agents designed to enhance the immune response against tumors. By identifying specific markers, such as PD-1 and CTLA-4, researchers can develop checkpoint inhibitors that block these pathways, allowing T cells to better attack cancer cells.

INNOVATIONS IN CSM TECHNOLOGIES FOR CANCER DIAGNOSIS

Recent advancements in technologies for analyzing CSM have significantly enhanced cancer diagnosis and monitoring. Techniques such as flow cytometry, mass cytometry, and single cell RNA sequencing provide detailed insights into the expression and functionality of surface markers on tumor cells. These technologies enable researchers to identify specific markers that indicate tumor types, stages and potential responses to therapies.

(1) Fonseca LN, et al. Cell surface markers for mesenchymal stem cells related to the skeletal system: A scoping review. Heliyon. (2023)10;9(2):e13464.

(2) Gosmann D, et al. Promise and challenges of clinical non-invasive T-cell tracking in the era of cancer immunotherapy. EJNMMI Res. (2022)31;12:5.

(3) Meyfour A, et al. The quest of cell surface markers for stem cell therapy. Cell Mol Life Sci. (2021) ;78(2):469-495.

CELLULAR SURFACE MARKERS BIOMARKER LIST

Customize your own signaling pathways (SignArrays®) with the factors of your choice!
Simply download and complete our Personalized SignArrays® information file and send it at [email protected] to get started on your project.

You can check the biomarker list included in this pathway, see below:

Species : Homo sapiens (human)

Signaling Pathways	Product ref	Informations
Cell Surface Markers	CSM1H1	List infos

Species : Mus musculus (mouse)

Signaling Pathways	Product ref	Informations
Cell Surface Markers	CSM1M1	List infos

Species : Rattus norvegicus (rat)

Signaling Pathways	Product ref	Informations
Cell Surface Markers	*******	List In progress...

Species : Sus Scrofa (Pig)

Signaling Pathways	Product ref	Informations
Cell Surface Markers	*******	List In progress...

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