HIF-1 Signaling Pathway

Hypoxia-inducible factor 1 (HIF-1), principal component of HIF-1 pathway, is a transcriptional activator induced by hypoxia, and a modulator of oxygen homeostasis and physiological responses ⁽¹⁾.

In hypoxic conditions, HIF-1 plays an essential role in the adaptation of cells and organs to changes related to the presence of oxygen ⁽⁵⁾, and it is required to maintain the pluripotency and survival of stem cells under hypoxic conditions ⁽⁶⁾.

HIF-1 Signaling Pathway and diseases

Hypoxia inducible factor-1 α (HIF-1α) is the key responder adapted to tumor hypoxia. Under hypoxia conditions, HIF-1α signaling is activated and responsible for cell biology associated with metabolism, inflammation, vascular homeostasis and tumorigenesis ⁽³⁾. HIF-1 regulates tumor biological behavior by influencing apoptotic/proliferative activity, vasomotor function, energy metabolism, and angiogenesis ⁽⁴⁾.

Previous research indicates that hypoxia increases the population of lung cancer stem cells resistant to gefitinib in EGFR mutation-positive NSCLC, and the HIF-1 signaling pathway is activated in EGFR-TKI-resistant lung cancer cells ⁽²⁾.
HIF-1α activation is related to the development of multidrug resistance and hypoxia-induced EMT in tumor cells ⁽⁴⁾. Moreover, recent findings suggest that HIF-1α-activated autophagy is a crucial factor in the promotion of cell survival under the distressed microenvironment, thereby leading to the chemo-/radioresistance ⁽⁷⁾.

The oncogenic and tumor suppressive activity of HIF in tumor and stromal cells ⁽⁵⁾ .

(1) Fu X et Zhang F. Role of the HIF-1 signaling pathway in chronic obstructive pulmonary disease. Exp Ther Med. (2018);16(6):4553-4561.

(2) Jin Q et al. Hypoxia-inducible factor-1 signaling pathway influences the sensitivity of HCC827 cells to gefitinib. Oncol Lett. (2019);17(4):4034-4043.

(3) Li H et al. Targeting HIF-1α signaling pathway for gastric cancer treatment. Pharmazie.(2019);74(1):3-7.

(4) Qin Y et al. Salidroside improves the hypoxic tumor microenvironment and reverses the drug resistance of platinum drugs via HIF-1α signaling pathway. EBioMedicine. (2018);38:25-36.

(5) Huang Y et al. Hypoxia inducible factor (HIF) in the tumor microenvironment: friend or foe? Sci China Life Sci. (2017);60(10):1114-1124.

(6) Lee HJ et al. Role of HIF1α Regulatory Factors in Stem Cells. Int J Stem Cells. (2019 );12(1):8-20.

(7) Xia Y et al. The role of HIF-1α in chemo-/radioresistant tumors. Onco Targets Ther. (2018); 11: 3003–3011.

Species : Homo sapiens (human)

Human HIF-1 Signaling Pathway

Signaling Pathways	Product ref	Informations
HIF-1 Signaling Pathway	HIF1H1	List infos

Species : Mus musculus (mouse)

Mouse HIF-1 Signaling Pathway

Signaling Pathways	Product ref	Informations
HIF-1 Signaling Pathway	HIF1M1	List infos

Species : Rattus norvegicus (rat)

Rat HIF-1 Signaling Pathway

Signaling Pathways	Product ref	Informations
HIF-1 Signaling Pathway	*******	List In progress...

Species : Sus Scrofa (Pig)

Pig HIF-1 Signaling Pathway

Signaling Pathways	Product ref	Informations
HIF-1 Signaling Pathway	*******	List In progress...

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