JAK-STAT pathway

The JAK-STAT pathway is an universally expressed intracellular signal transduction pathway and involved in many crucial biological processes, including cell proliferation, differentiation, apoptosis, and immune regulation ⁽¹⁾.

The schematic structures of the JAK and STAT proteins and overview of the JAK/STAT pathway ⁽⁴⁾ .

JAK-STAT pathway and diseases

Besides its important impact in cellular signaling, the JAK/STAT pathway has been associated with several diseases such as Rheumatoid arthritis, Parkinson’s disease, multiple sclerosis, sepsis ⁽¹⁾, inflammatory bowel disease ⁽²⁾, COVID-19 infection... ⁽⁴⁾.
Aberrant JAK/STAT signaling contributes to cancer progression and metastatic development including myeloproliferative neoplasms (MPNs), cutaneous T-cell lymphoma (CTCL), lung cancer, gastric cancer, prostate cancer, colon cancer. cervical cancer, breast cance... ^(1,3,5).

(1) Xin P, et al. The role of JAK/STAT signaling pathway and its inhibitors in diseases. Int Immunopharmacol. (2020);80:106210.

(2) Cordes F, et al. Differential regulation of JAK/STAT-signaling in patients with ulcerative colitis and Crohn's disease. World J Gastroenterol. (2020);26(28):4055-4075.

(3) Gutiérrez-Hoya A, & Soto-Cruz I. Role of the JAK/STAT Pathway in Cervical Cancer: Its Relationship with HPV E6/E7 Oncoproteins. Cells. (2020);9(10):2297.

(4) Goker Bagca B, & Biray Avci C.The potential of JAK/STAT pathway inhibition by ruxolitinib in the treatment of COVID-19. Cytokine Growth Factor Rev. (2020);54:51-62.

(5) Shao F, et al. Targeting the JAK/STAT Signaling Pathway for Breast Cancer. Curr Med Chem. (2021);28(25):5137-5151.

Species : Homo sapiens (human)

JAK-STAT-Pathway

Signaling Pathways	Product ref	Informations
JAK-STAT Signaling Pathway	JAK1H1	List infos

Species : Mus musculus (mouse)

Mouse JAK/STAT Signaling Pathway

Signaling Pathways	Product ref	Informations
JAK-STAT Signaling Pathway	JAK1M1	List infos

Species : Rattus norvegicus (rat)

Rat JAK/STAT Signaling Pathway

Signaling Pathways	Product ref	Informations
JAK-STAT Signaling Pathway	*******	List In progress...

Species : Sus Scrofa (Pig)

Pig JAK/STAT Pathway

Signaling Pathways	Product ref	Informations
JAK-STAT Signaling Pathway	*******	List In progress...

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