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JAK-STAT pathway  JAK-STAT pathway

The JAK-STAT pathway is an universally expressed intracellular signal transduction pathway and involved in many crucial biological processes, including cell proliferation, differentiation, apoptosis, and immune regulation (1).


The schematic structures of the JAK and STAT proteins and overview of the JAK/STAT pathway (4)

JAK-STAT pathway  JAK-STAT pathway and diseases

Besides its important impact in cellular signaling, the JAK/STAT pathway has been associated with several diseases such as Rheumatoid arthritis, Parkinson’s disease, multiple sclerosis, sepsis (1), inflammatory bowel disease (2), COVID-19 infection... (4).
Aberrant JAK/STAT signaling contributes to cancer progression and metastatic development including myeloproliferative neoplasms (MPNs), cutaneous T-cell lymphoma (CTCL), lung cancer, gastric cancer, prostate cancer, colon cancer. cervical cancer, breast cance... (1,3,5).
(1) Xin P, et al. The role of JAK/STAT signaling pathway and its inhibitors in diseases. Int Immunopharmacol. (2020);80:106210.
(2) Cordes F, et al. Differential regulation of JAK/STAT-signaling in patients with ulcerative colitis and Crohn's disease. World J Gastroenterol. (2020);26(28):4055-4075.
(3) Gutiérrez-Hoya A, & Soto-Cruz I. Role of the JAK/STAT Pathway in Cervical Cancer: Its Relationship with HPV E6/E7 Oncoproteins. Cells. (2020);9(10):2297.
(4) Goker Bagca B, & Biray Avci C.The potential of JAK/STAT pathway inhibition by ruxolitinib in the treatment of COVID-19. Cytokine Growth Factor Rev. (2020);54:51-62.
(5) Shao F, et al. Targeting the JAK/STAT Signaling Pathway for Breast Cancer. Curr Med Chem. (2021);28(25):5137-5151.
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