Innate & Adaptive Immune Response

The immune system has two important branches, Innate and adaptive immunity which plays essential role for health and initiation and progression of chronic inflammatory diseases ⁽¹⁾.

Innate-adaptive immunity interplay in immune response ⁽¹⁾ .

The recognized characteristic in the innate and adaptive immune system is ''Memory ''' which enhances host survival upon reinfection ⁽²⁾.

Immune Response and diseases

Studies have proven that dysfunction of innate and adaptive immune response is considered to be a key step in the initiation and maintenance of autoimmune diseases ⁽³⁾, atherosclerosis ⁽⁴⁾, COVID-19 ⁽⁵⁾, Parkinson's disease …⁽⁶⁾.

(1) Sun L, et al. Innate-adaptive immunity interplay and redox regulation in immune response. Redox Biol. (2020);37:101759.

(2) Netea MG, et al. Innate and Adaptive Immune Memory: an Evolutionary Continuum in the Host's Response to Pathogens. Cell Host Microbe. (2019);25(1):13-26.
(3) Zhang Y, et al. NLRP3 Inflammasome: Checkpoint Connecting Innate and Adaptive Immunity in Autoimmune Diseases. Front Immunol. (2021);12:732933.
(4) Roy P, et al. How the immune system shapes atherosclerosis: roles of innate and adaptive immunity. Nat Rev Immunol. (2022);22(4):251-265.
(5) Carsetti R, et al. Different Innate and Adaptive Immune Responses to SARS-CoV-2 Infection of Asymptomatic, Mild, and Severe Cases. Front Immunol. (2020);11:610300.
(6) Schonhoff AM, et al. Innate and adaptive immune responses in Parkinson's disease. Prog Brain Res. (2020);252:169-216

Species : Homo sapiens (human)

Innate and Adaptive Immune response Human

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Species : Mus musculus (mouse)

Mouse Innate and Adaptive Immune response

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Species : Rattus norvegicus (rat)

Rat Innate and Adaptive Immunne response

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Species : Sus Scrofa (Pig)

Innate and Adaptive Immunne response Pig

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