NITRIC OXIDE PATHWAY

The function of the nitric oxide pathway is dependent on nitric oxide (NO), a potent signaling molecule. This pathway is essential for the regulation of various cellular processes in both healthy and diseased states. These processes include immune response, heart function, reproduction, muscle control, and nervous system activity. Additionally, the pathway is also responsible for vasodilation, neurotransmission, cell movement, and programmed cell death.

NO exerts numerous effects on the kidneys, heart and vasculature as well as on peripheral metabolically active organs ^(1,2,3).

The NOS pathway and potential effects of NO on cardiovascular,renal and metabolic functions ⁽²⁾.

Various cells in the body produce NO internally through three different NOS systems. Neuronal NOS (nNOS or NOS1) and endothelial NOS (eNOS or NOS3) are consistently present. While inducible NOS (iNOS or NOS2) primarily links to inflammatory situations.

Neural NOS (nNOS) and endothelial NOS (eNOS) produce small amounts of NO. This, can act as a neurotransmitter, vasodilator, or assist in the release of insulin. While inducible NOS (iNOS) produces significant quantities of NO in order to fight against pathogens ^(2,5).

THE LINK BETWEEN NITRIC OXIDE AND DISEASES

NO has a complex and multifaceted role in cancer (breast, lung, prostate, colon, gastric, pancreatic, ovarian, and neuroblastoma), aging, cardiovascular pathogenesis, ocular hypertension, Glaucoma … ^(3,4,5,6).

(1) Kopp-Scheinpflug C et al. Nitric Oxide Signaling in the Auditory Pathway. Front Neural Circuits. (2021);15:759342.

(2) Carlström M. Nitric oxide signalling in kidney regulation and cardiometabolic health. Nat Rev Nephrol. (2021);17(9):575-590.

(3) López-Sánchez LM et al. Nitric oxide and tumor metabolic reprogramming. Biochem Pharmacol. (2020);176:113769.

(4) Pourbagher-Shahri AM et al. An Overview of NO Signaling Pathways in Aging. Molecules. (2021);26(15):4533.

(5) Liu X et al. Protein Phosphorylation in Cancer: Role of Nitric Oxide Signaling Pathway. Biomolecules. (2021);11(7):1009.

(6) Reina-Torres E et al. The vital role for nitric oxide in intraocular pressure homeostasis. Prog Retin Eye Res. (2021);83:100922

NITRIC OXYDE SIGNALING PATHWAY BIOMARKER LIST

You can custom your own SignArrays® with the genes of interest of your choice, according to your project, you just have to download and complete our Personalized SignArrays® information file and send it at [email protected]

You can check the biomarker list included in this pathway, see below: .

Species : Homo sapiens (human)

Human Signaling Pathway

Signaling Pathways	Product ref	Informations
Nitric Oxide Signaling Pathway	NO1H1	List infos

Species : Mus musculus (mouse)

Mouse Signaling Pathway

Signaling Pathways	Product ref	Informations
Nitric Oxide Signaling Pathway	NO1M1	List infos

Species : Rattus norvegicus (rat)

Rat Signaling Pathway

Signaling Pathways	Product ref	Informations
Nitric Oxide Signaling Pathway	*******	List In progress...

Species : Sus Scrofa (Pig)

Pig Signaling Pathway

Signaling Pathways	Product ref	Informations
Nitric Oxide Signaling Pathway	*******	List In progress...

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