WHAT ARE GROWTH FACTORS?

Growth factors (GF) are essential proteins that play a critical role in regulating cell growth, differentiation, and healing. These signaling molecules bind to specific receptors on the surface of target cells, initiating a cascade of biochemical reactions that influence various cellular processes, such as proliferation, migration, and apoptosis.

At AnyGenes, we offer specialized qPCR arrays for studying the expression of key growth factors and their signaling pathways across various species. Our cutting-edge tools support researchers in understanding the mechanisms of growth factor-driven diseases and developing new therapeutic approaches.

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TYPES OF GROWTH FACTORS

GF can be classified into several families based on their structural and functional characteristics. Some key families include:

Epidermal Growth Factor (EGF): Stimulates cell growth and differentiation, especially in epithelial tissues.
Platelet-Derived Growth Factor (PDGF): Involved in blood vessel formation, tissue repair, and the development of cancer.
Vascular Endothelial Growth Factor (VEGF): Promotes the formation of new blood vessels (angiogenesis), crucial for tissue repair and tumor growth.
Fibroblast Growth Factor (FGF): Plays a role in wound healing and embryonic development.

THE IMPORTANCE OF CELLULAR GROWTH PROTEINS IN TISSUE REPAIR

GF are integral to the healing process, particularly after injuries or surgeries. For instance:

Platelet-Derived Growth Factor (PDGF) is released by platelets at the injury site, attracting other cells necessary for healing.
Transforming Growth Factor-beta (TGF-β) regulates immune responses and tissue remodeling during the healing phases.

GROWTH FACTORS AND CELL SIGNALING PATHWAYS

Cellular growth proteins act as crucial messengers in various cell signaling pathways. These pathways, such as the MAPK, PI3K/Akt, and JAK/STAT pathways, are essential for transmitting signals from the cell surface to the nucleus. By activating these pathways, cellular growth molecules regulate gene expression, promoting cell survival, division, and differentiation. Understanding how GF interact with signaling pathways is vital for developing therapies that target abnormal cell growth and cancer.

APPLICATIONS IN REGENERATIVE MEDICINE

Cellular growth proteins play a pivotal role in regenerative medicine, where they are used to promoting tissue repair and regeneration. For instance, fibroblast growth factors (FGFs) are used to stimulate wound healing, while vascular endothelial growth factors (VEGFs) aid in blood vessel formation. For instance, agents targeting the epidermal growth factor receptor (EGFR) have shown promise in treating various solid tumors. GF therapies are being explored in areas such as tissue engineering, stem cell research, and the treatment of degenerative diseases.

(1) Matsuoka T, Yashiro M. The Role of the Transforming Growth Factor-β Signaling Pathway in Gastrointestinal Cancers. Biomolecules.(2023)19;13(10):1551.

(2) Grant ZL, Coultas L. Growth factor signaling pathways in vascular development and disease.Growth Factors. (2019);37(1-2):53-67.

(3) Huang J, Zhao L, Chen D. Growth factor signalling in osteoarthritis. Growth Factors.(2018);36(5-6):187-195.

GROWTH FACTORS BIOMARKER LIST

Customize your own signaling pathways (SignArrays®) with the factors of your choice!
Simply download and complete our Personalized SignArrays® information file and send it at [email protected] to get started on your project.

You can check the biomarker list included in this pathway, see below:

Species : Homo sapiens (human)

Signaling Pathways	Product ref	Informations
Growth Factors	GF1H1	List infos

Species : Mus musculus (mouse)

Signaling Pathways	Product ref	Informations
Growth Factors	GF1M1	List infos

Species : Rattus norvegicus (rat)

Signaling Pathways	Product ref	Informations
Growth Factors	*******	List In progress...

Species : Sus Scrofa (Pig)

Signaling Pathways	Product ref	Informations
Growth Factors	*******	List In progress...

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