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signaling pathway   NFKB Pathway

NFKB Pathway with its important nuclear transcription factor NF-κB, which plays a key regulatory role in innate immunity, acquired immunity, inflammatory response and the progression of tumors (1).


Schematic diagram of the canonical and non-canonical Nuclear factor kappa B (NF-κB) signaling pathways (3)

signaling pathway  NFKB signaling pathway and diseases

Nuclear factor kappa B (NF-κB) signaling is implicated in both normal physiology and in the development of a multitude of diseases such as inflammation, diabetes, cancer (breast cancer, ovarian cancer, prostate cancer, gastric carcinoma and colorectal cancer), autoimmune disorders and neurodegeneratives diseases (2,3,4).
(1) Wang Y, et al. NF-κB signaling in skin aging. Mech Ageing Dev. (2019);184:111160.
(2) Soleimani A, et al. Role of the NF-κB signaling pathway in the pathogenesis of colorectal cancer. Gene. (2020);726:144132.
(3) Ramadass V, et al. Small Molecule NF-κB Pathway Inhibitors in Clinic. Int J Mol Sci. (2020);21(14):5164.
(4) Singh S, & Singh TG. Role of Nuclear Factor Kappa B (NF-κB) Signalling in Neurodegenerative Diseases: An Mechanistic Approach. Curr Neuropharmacol. (2020);18(10):918-935
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