NFKB Pathway

NFKB Pathway with its important nuclear transcription factor NF-κB, which plays a key regulatory role in innate immunity, acquired immunity, inflammatory response and the progression of tumors ⁽¹⁾.

Schematic diagram of the canonical and non-canonical Nuclear factor kappa B (NF-κB) signaling pathways ⁽³⁾ .

NFKB signaling pathway and diseases

Nuclear factor kappa B (NF-κB) signaling is implicated in both normal physiology and in the development of a multitude of diseases such as inflammation, diabetes, cancer (breast cancer, ovarian cancer, prostate cancer, gastric carcinoma and colorectal cancer), autoimmune disorders and neurodegeneratives diseases ^(2,3,4).

(1) Wang Y, et al. NF-κB signaling in skin aging. Mech Ageing Dev. (2019);184:111160.

(2) Soleimani A, et al. Role of the NF-κB signaling pathway in the pathogenesis of colorectal cancer. Gene. (2020);726:144132.

(3) Ramadass V, et al. Small Molecule NF-κB Pathway Inhibitors in Clinic. Int J Mol Sci. (2020);21(14):5164.

(4) Singh S, & Singh TG. Role of Nuclear Factor Kappa B (NF-κB) Signalling in Neurodegenerative Diseases: An Mechanistic Approach. Curr Neuropharmacol. (2020);18(10):918-935

Species : Homo sapiens (human)

Human Signaling Pathway

Signaling Pathways	Product ref	Informations
NFKB Signaling Pathway	NFKB1H1	List infos

Species : Mus musculus (mouse)

Mouse Signaling Pathway

Signaling Pathways	Product ref	Informations
NFKB Signaling Pathway	NFKB1M1	List infos

Species : Rattus norvegicus (rat)

Rat Signaling Pathway

Signaling Pathways	Product ref	Informations
NFKB Signaling Pathway	*******	List In progress...

Species : Sus Scrofa (Pig)

Pig Signaling Pathway

Signaling Pathways	Product ref	Informations
NFKB Signaling Pathway	*******	List In progress...

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