The cell microenvironment (1)
The micro-cellular environment encompasses neighboring cells and their direct environment:
The ECM is a major element of the cell’s microenvironment. In fact, the cell is able to anchor itself and move, by interacting with the ECM. The ECM itself in composed of many elements: (laminins, collagen, fibronectins, elastins, etc.) In physiological conditions, the microenvironment of the cell provides a tumor suppressor role.
Role of the tumor microenvironment in tumor progression and the clinical applications (Review) (2016)
Cancer cells can create for themselves an ideal environment, suited to their survival and proliferation. To do so, they can reprogram the metabolism of cells present in their environment (such as fibroblasts) and use it to their advantage, in order to induce growth and survival signals.
Moreover, the secretion of various factors (pro-angiogenic factors (VEGFA, PDGFA & PDGFB, FGF1 & FGF2…), pro-inflammatory factors (TNFA, IL8…) or anti-inflammatory factors (IL10, TGFB…)) and the interaction between tumor cells and surrounding cells can lead to the activation of several signaling pathways or mechanisms such as angiogenesis, adhesion-migration-invasion, cell proliferation, which will promote the colonization of new tissues through metastasis. (3) (4)
Those elements prove that the TME is deeply involved in tumor growth and proliferation.
AnyGenes® offers you the possibility to perform a high-throughput analysis of the TME to understand and identify the different signaling pathways involved, thanks to a single transcriptomic analysis.
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