The cell microenvironment
The micro-cellular environment encompasses neighboring cells and their direct environment:
The ECM is a major element of the cell’s microenvironment. In fact, the cell is able to anchor itself and move, by interacting with the ECM. The ECM itself in composed of many elements: (laminins, collagen, fibronectins, elastins, etc.) In physiological conditions, the microenvironment of the cell provides a tumor suppressor role.
Role of the tumor microenvironment in tumor progression and the clinical applications (Review) (2016)
Those elements prove that the TME is deeply involved in tumor growth and proliferation.
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