Inflammation

Inflammation is the adaptive response to various stimuli (toxins, viruses, bacteria, ischemia, or necrotic tissue, trauma ...) to which we are exposed ⁽¹⁾.

In addition, inflammation may develop as a result of immune dysregulation in autoimmune or malignant disorders such as rheumatologic disorders, inflammatory bowel disease... ⁽²⁾.

Inflammation and diseases

The recent studies for immune response to SARS-CoV-2 have shown that the critical point where progression of the coronavirus disease 2019 (COVID-19) ensues appears to center on loss of the immune regulation between protective and altered responses due to exacerbation of the inflammatory components ⁽³⁾.

Schematic representation of SARS-CoV-2-driven signaling pathways and potential drug targets ⁽⁴⁾ .

Other diseases in which inflammation is involved: malignant tumours and atherosclerotic plaques, alzheimer, pulmonary disease, periodontitis, age and in psychiatric disorders including major depression, schizophrenia and bipolar disorder ^(5-8).

(1) Miguel Lourenço Varela et al. Acute Inflammation and Metabolism. Inflammation. (2018);41(4):1115-1127.

(2) Tomas Ganz. Anemia of Inflammation. N Engl J Med. (2019);381(12):1148-1157.

(3) Luis F García. Immune Response, Inflammation, and the Clinical Spectrum of COVID-19. Front Immunol. (2020);11:1441.

(4) Michele Catanzaro et al. Immune response in COVID-19: addressing a pharmacological challenge by targeting pathways triggered by SARS-CoV-2. Signal Transduct Target Ther. (2020);5(1):84.

(5) Ning Yuan et al. Inflammation-related biomarkers in major psychiatric disorders: a cross-disorder assessment of reproducibility and specificity in 43 meta-analyses. Transl Psychiatry. (2019);9(1):233.

(6) Estella A Newcombe et al. Inflammation: the link between comorbidities, genetics, and Alzheimer's disease. J Neuroinflammation. 2018;15(1):276.

(7) Christina H Liu et al. Biomarkers of chronic inflammation in disease development and prevention: challenges and opportunities. Nat Immunol. 2017;18(11):1175-1180.

(8) Peter Libby and Sebastian Kobold. Inflammation: a common contributor to cancer, aging, and cardiovascular diseases—expanding the concept of cardio-oncology. Cardiovasc Res. 2019;115(5): 824–829.

Species : Homo sapiens (human)

Human Inflammation

Signaling Pathways	Product ref	Informations
Inflammation	IF1H1	List infos

Species : Mus musculus (mouse)

Mouse Inflammation

Signaling Pathways	Product ref	Informations
Inflammation	IF1M1	List infos

Species : Rattus norvegicus (rat)

Rat Inflammation

Signaling Pathways	Product ref	Informations
Inflammation	IF1R1	List infos

Species : Sus Scrofa (Pig)

Pig Inflammation

Signaling Pathways	Product ref	Informations
Inflammation	*******	List In progress...

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