T HELPER CELLS, IMMUNE SYSTEM ALARM

CD4+ T cells are the central element of the adaptive immune responses and protect the body from a variety of pathogens by helping B lymphocytes to produce antibodies (Ab) and by secreting specific cytokines that provide efficient protection against pathogens ^(1,3).

CD4+ T cells development and their functional subsets in immunity ⁽⁴⁾ .

T HELPER (TH) CELLS AND DISEASES

CD4+ T helper (Th) cells play pivotal roles in many inflammatory and autoimmune diseases such as multiple sclerosis (MS), rheumatoid arthritis (RA), psoriasis, inflammatory bowel diseases, viral infections and tumorigenesis ^(1,2,3,4).

(1) Wan Z, et al. Regulatory T cells and T helper 17 cells in viral infection. Scand J Immunol. (2020);91(5):e12873.

(2) Yasuda K, et al. The pathogenicity of Th17 cells in autoimmune diseases. Semin Immunopathol. (2019);41(3):283-297.

(3) Kunkl M, et al. T Helper Cells: The Modulators of Inflammation in Multiple Sclerosis. Cells. (2020);9(2):482.

(4) Basu A, et al. Differentiation and Regulation of T H Cells: A Balancing Act for Cancer Immunotherapy. Front Immunol. (2021);12:669474.

T HELPER CELLS SIGNALING PATHWAY BIOMARKER LIST

You can custom your own SignArrays® with the genes of interest of your choice, according to your project, you just have to download and complete our Personalized SignArrays® information file and send it at [email protected]

You can check the biomarker list included in this pathway, see below: .

Species : Homo sapiens (human)

Human T Helper Cells Signaling Pathway

Signaling Pathways	Product ref	Informations
T Helper Cells Signaling Pathway	THS1H1	List infos

Species : Mus musculus (mouse)

Mouse T Helper Cells Signaling Pathway

Signaling Pathways	Product ref	Informations
T Helper Cells Signaling Pathway	THS1M1	List infos

Species : Rattus norvegicus (rat)

Rat T Helper Cells Signaling Pathway

Signaling Pathways	Product ref	Informations
T Helper Cells Signaling Pathway	*******	List In progress...

Species : Sus Scrofa (Pig)

Pig T Helper Cells Signaling Pathway

Signaling Pathways	Product ref	Informations
T Helper Cells Signaling Pathway	*******	List In progress...

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