Cell proliferation: key processes in health and diseases
Cell proliferation is the process by which cells grow and divide, playing a fundamental role in tissue development, regeneration and repair. In normal conditions, cellular proliferation is tightly regulated, ensuring balance of growth. However, abnormal cellular proliferation is a hallmark of various diseases, including cancer and autoimmune disorders.
At AnyGenes, we provide advanced qPCR arrays (SignArrays®) to help researchers analyze the expression of genes involved in cellular proliferation. Our customizable arrays cover a broad range of species, including human, mouse, rat and pig, offering precise solutions for studying key pathways and other conditions related to abnormal cell growth.
Protein Kinases: such as PKC (Protein Kinase C), ATM/ATR/DNA-PK.
Tumor Suppressors: p53, RB1.
Oncogene and proto-oncogenes: like RAS and AKT.
Ki-67 and PCNA (Proliferating Cell Nuclear Antigen)
Role of cell proliferation in cancer progression
One of the most critical aspects of cell growth is its role in cancer progression. Under normal conditions, cell growth is tightly regulated. However, in cancer, these controls are often bypassed, leading to uncontrolled cell growth and tumor formation. Mutation in oncogenes and inactivation of tumor suppressor genes like p53 and RB1 facilitate this unchecked growth.
Therapeutics targeting of cellular proliferation pathway
Targeting cellular proliferation pathways is a key strategy in developing anticancer therapies. Many drugs specifically target the signaling pathway that control proliferation, such as kinase inhibitors that block proteins in the PI3K/AKT/mTOR or MAPK/ERK pathways.
Analyze your pathway data with AnyGenes® software
Scientific data is only as powerful as the analysis behind it.
AnyGenes® provides a dedicated data analysis tool specifically developed for SignArrays® pathway panels.
What does it allow you to do?
Automated ΔCq calculation
Normalization with selected housekeeping genes
Comparison of up to 10 experimental conditions
Generation of descriptive statistics
Publication-ready graphs
Exportable tables for manuscripts and presentations
Developed on Excel (compatible with 2007+), the software is user-friendly and requires no advanced bioinformatics skills.
Looking for more answers? Visit our Help & FAQ section to find detailed informations about our products, services, and technical support.
Bibliography
1. Wang K, et al. A Systematic Analysis Identifies Key Regulators Involved in Cell Proliferation and Potential Drugs for the Treatment of Human Lung Adenocarcinoma. Front Oncol. (2021)28;11:737152.
2. Nussinov R, et al. Are Parallel Proliferation Pathways Redundant? Trends Biochem Sci. (2020);45(7):554-563.
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