CELL PROLIFERATION: KEY PROCESSES IN HEALTH AND DISEASES

Cell proliferation is the process by which cells grow and divide, playing a fundamental role in tissue development, regeneration and repair. In normal conditions, cellular proliferation is tightly regulated, ensuring balance of growth. However, abnormal cellular proliferation is a hallmark of various diseases, including cancer and autoimmune disorders.

At AnyGenes, we provide advanced qPCR arrays (SignArrays^®) to help researchers analyze the expression of genes involved in cellular proliferation. Our customizable arrays cover a broad range of species, including human, mouse, rat and pig, offering precise solutions for studying key pathways and other conditions related to abnormal cell growth.

Discover our advanced qPCR arrays for Cell Proliferation research.

Examples of Parallel and Redundant Pathways in Proliferation of cell.

MECHANISMS AND SIGNALING PATHWAYS IN PROLIFERATION OF CELL

The regulation of cell growth involves complex signaling pathways that control when and how cells divide. Key pathways include:

PI3K/AKT/mTOR pathway: govern cell growth and metabolism, influencing cancer cell reproduction.
Wnt/β-catenin Pathway: plays a role in embryonic development and tissue homeostasis, with dysregulation linked to cancer.
MAPK/ERK pathway: crucial for cell cycle progression and proliferation, often overactive in cancer.

KEY MOLECULES INVOLVED IN CELLULAR PROLIFERATION

Cyclins and Cyclin-Dependent-Kinases (CDKs): including Cyclin D, Cyclin E, Cyclin A, Cyclin B.
Growth factors: like Epidermal Growth Factor (EGF), Hepatocyte Growth Factor (c-Met).
Transcription Factors: like E2F family, AP-1.
Protein Kinases: such as PKC (Protein Kinase C), ATM/ATR/DNA-PK.
Tumor Suppressors: p53, RB1.
Oncogene and proto-oncogenes: like RAS and AKT.
Ki-67 and PCNA (Proliferating Cell Nuclear Antigen)

ROLE OF CELL PROLIFERATION IN CANCER PROGRESSION

One of the most critical aspects of cell growth is its role in cancer progression. Under normal conditions, cell growth is tightly regulated. However, in cancer, these controls are often bypassed, leading to uncontrolled cell growth and tumor formation. Mutation in oncogenes and inactivation of tumor suppressor genes like p53 and RB1 facilitate this unchecked growth.

THERAPEUTICS TARGETING OF CELLULAR PROLIFERATION PATHWAY

Targeting cellular proliferation pathways is a key strategy in developing anticancer therapies. Many drugs specifically target the signaling pathway that control proliferation, such as kinase inhibitors that block proteins in the PI3K/AKT/mTOR or MAPK/ERK pathways.

Wang K, et al. A Systematic Analysis Identifies Key Regulators Involved in Cell Proliferation and Potential Drugs for the Treatment of Human Lung Adenocarcinoma. Front Oncol. (2021)28;11:737152.
Nussinov R, et al. Are Parallel Proliferation Pathways Redundant? Trends Biochem Sci. (2020) ;45(7):554-563.

CELLULAR PROLIFERATION BIOMARKER LIST

Customize your own signaling pathways (SignArrays^®) with the factors of your choice!
Simply download and complete our Personalized SignArrays^® information file and send it at [email protected] to get started on your project.

You can check the biomarker list included in this pathway, see below:

Species : Homo sapiens (human)

Human signaling pathway

Signaling Pathways	Product ref	Informations
Cell Proliferation	CP1H1	List infos

Species : Mus musculus (mouse)

Mouse signaling pathway

Signaling Pathways	Product ref	Informations
Cell Proliferation	CP1M1	List infos

Species : Rattus norvegicus (rat)

Rat Cell Proliferation

Signaling Pathways	Product ref	Informations
Cell Proliferation	*******	List In progress...

Species : Sus Scrofa (Pig)

Pig Cell Proliferation

Signaling Pathways	Product ref	Informations
Cell Proliferation	*******	List In progress...

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