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The PI3K/Akt signaling pathway is a central intracellular signaling cascade that regulates proliferation, angiogenesis, cell growth, survival, metabolism, and motility. It is activated by extracellular signals such as growth factors, cytokines, hormones, and nutrients.
Upon activation, phosphoinositide 3-kinase (PI3K) converts PIP2 into PIP3, leading to recruitment and activation of AKT (Protein Kinase B). Activated AKT phosphorylates a wide range of downstream substrates controlling cell fate decisions.
Dysregulation of PI3K/AKT signaling is one of the most frequent molecular alterations in cancer, and is also implicated in metabolic, cardiovascular, and neurodegenerative diseases.
PI3K/AKT signaling pathway biomarker list
View the genes included in our PI3K/AKT pathway qPCR arrays.
Catalyzes the production of PIP3, initiating AKT activation.
Central kinase regulating metabolism, proliferation, and anti-apoptotic signaling.
Downstream effector controlling protein synthesis, cell growth, and metabolism.
Tumor suppressor that negatively regulates PI3K signaling by dephosphorylating PIP3.
Cancer: Hyperactivation promotes:
Mutations in PIK3CA, AKT, or loss of PTEN are common across solid tumors.
Metabolic diseases: Altered signaling contributes to:
Neurodegenerative and cardiovascular diseases: PI3K/AKT dysregulation affects neuronal survival and cardiac function
PI3K/AKT signaling interacts extensively with:
This network integration makes PI3K/AKT a central hub in cellular signaling
Because of its central role, PI3K/AKT is a major therapeutic target:
Accurate biomarker profiling is essential to guide therapeutic strategies
At AnyGenes®, we provide high-performance qPCR arrays and customizable SignArrays® for PI3K/AKT pathway analysis and biomarker discovery.
Our solutions allow researchers to:
What can be analyzed?
Scientific data is only as powerful as the analysis behind it.
AnyGenes® provides a dedicated data analysis tool specifically developed for SignArrays® pathway panels.
What does it allow you to do?
Developed on Excel (compatible with 2007+), the software is user-friendly and requires no advanced bioinformatics skills.
Customize your own signaling pathways (SignArrays®) with the factors of your choice!
Simply download and complete our Personalized SignArrays® information file
and send it at
[email protected]
to initiate your project.
It is activated by growth factor receptors, leading to PI3K-mediated PIP3 production and AKT activation, which regulates cell survival, growth, and metabolism.
Key genes include PIK3CA, AKT1/2/3, PTEN, and mTOR.
Hyperactivation promotes tumor growth, survival, and resistance to therapy.
By measuring expression of pathway regulators and downstream targets using targeted gene expression approaches such as qPCR pathway arrays.
| Signaling Pathways | Product ref | Informations |
|---|---|---|
PI3K-AKT Signaling Pathway | AKT1H1 |
| Signaling Pathways | Product ref | Informations |
|---|---|---|
PI3K-AKT Signaling Pathway | AKT1M1 |
| Signaling Pathways | Product ref | Informations |
|---|---|---|
PI3K-AKT Signaling Pathway | ******* |
Biomarker list in progress. |
| Signaling Pathways | Product ref | Informations |
|---|---|---|
PI3K-AKT Signaling Pathway | ******* |
Biomarker list in progress. |
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1. Jafari M et al. PI3k/AKT signaling pathway: Erythropoiesis and beyond. J Cell Physiol. (2019);234(3):2373-2385.
2. He Y et al. Targeting PI3K/Akt signal transduction for cancer therapy.Signal Transduct Target Ther. (2021);6(1):425.
3. Liu R et al. PI3K/AKT pathway as a key link modulates the multidrug resistance of cancers. Cell Death Dis. (2020);11(9):797.
4. Teng Y et al. The PI3K/Akt Pathway: Emerging Roles in Skin Homeostasis and a Group of Non-Malignant Skin Disorders. Cells. (2021);10(5):1219.
5. Chu E et al. Dysregulated phosphoinositide 3-kinase signaling in microglia: shaping chronic neuroinflammation. J Neuroinflammation. (2021);18(1):276.