What are Long Non Coding RNAs (LncRNAs)?

Long non coding RNAs (lncRNAs) are a diverse class of RNA molecules longer than 200 nucleotides that do not encode proteins but play critical roles in regulating gene expression, cellular processes, and development. Unlike messenger RNAs (mRNAs), lncRNAs function by interacting with DNA, RNA, and proteins to modulate gene activity, chromatin structure, and cellular pathways. They are involved in essential biological processes such as cellular differentiation, proliferation, and apoptosis.

Why Choose AnyGenes® for lncRNA Research?

AnyGenes^® offers state-of-the-art qPCR arrays designed specifically for the study of long non-coding RNAs. Our comprehensive solutions enable researchers to:

Investigate key lncRNAs involved in gene regulation and cellular processes.
Study the expression profiles of lncRNAs in various tissues and diseases.
Analyze the interactions between lncRNAs and other genetic elements, including mRNAs and microRNAs.
Uncover the roles of lncRNAs in diseases like cancer, neurodegenerative disorders, and metabolic diseases.

With AnyGenes^® qPCR arrays, you can obtain accurate and reproducible data to further your research into the complex world of lncRNAs.

Discover our advanced qPCR arrays for Long Non Coding RNAs research.

lncRNAs in Cancer Phenotypes Long Noncoding RNAs in Cancer Pathways. Cancer Cell. 2016.

Functions of long non coding RNA

lncRNAs serve a variety of functions in cellular biology, including:

Gene Regulation: lncRNAs can regulate gene expression at multiple levels, including transcriptional, post-transcriptional, and epigenetic.
Chromatin Remodeling: Many lncRNAs play a role in modifying chromatin structure, affecting how genes are accessed and expressed.
Cellular Differentiation and Development: lncRNAs are key players in stem cell differentiation, tissue development, and cellular reprogramming.
Regulation of Cellular Pathways: They influence signaling pathways such as the p53, Wnt, and Notch pathways, crucial for cell cycle regulation and survival.

Types of long non coding RNA structures

LncRNAs can adopt various structures, enabling diverse biological functions:

Linear LncRNAs: Single-stranded RNAs that regulate gene expression through interactions with chromatin and proteins.
Circular RNAs (circRNAs): Stable, circular structures that act as microRNA sponges, influencing gene regulation.
LncRNAs with Structural Domains: Contain motifs that bind to proteins or RNA, regulating transcription and chromatin remodeling.
Multidomain LncRNAs: Have multiple functional domains to coordinate complex cellular processes.
RNA Secondary and Tertiary Structures: Complex folding patterns that enhance interactions with other molecules, affecting gene regulation.

These structural types allow LncRNAs to perform key roles in gene regulation and cellular functions.

LncRNAs and diseases

Abnormal lncRNA expression is linked to various diseases, including:

Cancer: lncRNAs can promote or inhibit tumorigenesis by regulating tumor suppressor genes and oncogenes.
Neurological Disorders: Dysregulation of lncRNAs has been associated with diseases such as Alzheimer’s, Parkinson’s, and Huntington’s disease.
Cardiovascular Diseases: Certain lncRNAs regulate heart development and function, and their dysregulation may contribute to conditions like heart failure and atherosclerosis.
Metabolic Disorders: lncRNAs are involved in regulating insulin sensitivity and lipid metabolism, making them key in conditions like obesity and diabetes.

Therapeutic applications

LncRNA research has wide-ranging applications, including:

Biomarker Discovery: LncRNAs can be used as biomarkers for disease diagnosis, prognosis, and treatment response.
Therapeutic Targeting: By targeting specific LncRNAs, researchers are exploring novel therapeutic strategies for diseases like cancer and neurological disorders.
Gene Expression Profiling: LncRNA expression analysis helps to understand the intricate regulatory networks governing cellular processes and disease.

In 2015, Iyer MK et al. identified nearly 58,000 long non-coding RNAs (lncRNAs), highlighting their regulatory roles in tissue physiology and their involvement in diseases such as cancer, cardiovascular disorders, and autoimmune conditions. These versatile molecules are highly prevalent throughout the human body, making them valuable biomarkers.

In 2016, Schmitt AM and Chang HY further revealed that 499 lncRNAs are critical for cell growth, with 89% exhibiting cell-type-specific functions. This underscores the significance of lncRNAs in both health and disease, offering potential for targeted therapeutic applications.

Analyze your pathway data with AnyGenes® software

Scientific data is only as powerful as the analysis behind it.

AnyGenes® provides a dedicated data analysis tool specifically developed for SignArrays® pathway panels.

What does it allow you to do?

Automated ΔCq calculation
Normalization with selected housekeeping genes
Comparison of up to 10 experimental conditions
Generation of descriptive statistics
Publication-ready graphs
Exportable tables for manuscripts and presentations

Developed on Excel (compatible with 2007+), the software is user-friendly and requires no advanced bioinformatics skills.

Customize your own signaling pathways (SignArrays®) with the factors of your choice!
Simply download and complete our Personalized SignArrays® information file and send it at [email protected] to initiate your project.

LncRNA biomarker list

You can check the biomarker list included in this pathway, see below:

Species : Homo sapiens (human)

Human LncRNAs pathway

Signaling Pathways	Product ref	Informations
LncRNAs and Autoimmune Diseases	LNCA1H1	Download biomarker list
LncRNAs and Cancer	LNCC1H1	Download biomarker list
LncRNAs and Inflammatory & Immune Response	LNCI1H1	Download biomarker list
LncRNAs and Neurodegenerative Diseases	LNCN1H1	Download biomarker list
LncRNAs and Proliferation	LNCP1H1	Download biomarker list
Long Non Coding RNA main list	LncRNAs	Download biomarker list
LncRNAs and Cardiovascular Diseases	LNCV1H1	Download biomarker list

Species : Mus musculus (mouse)

Mouse LncRNAs pathway

Signaling Pathways	Product ref	Informations
Long Non Coding RNA	*******	Biomarker list in progress.

Species : Rattus norvegicus (rat)

Rat LncRNAs pathway

Signaling Pathways	Product ref	Informations
Long Non Coding RNA	*******	Biomarker list in progress.

Species : Sus Scrofa (Pig)

Pig Long Non Coding RNA

Signaling Pathways	Product ref	Informations
Long Non Coding RNA	*******	Biomarker list in progress.

Looking for more answers? Visit our Help & FAQ section to find detailed informations about our products, services, and technical support.

Bibliography

1. The ENCODE Project Consortium. An integrated encyclopedia of DNA elements in the human genome. Nature. (2012);489(7414):57-74.

2. Frith MC, et al. Discrimination of non-protein-coding transcripts from protein-coding mRNA. RNA Biol. (2006);3(1):40-8.

3. Iyer MK, et al. The landscape of long noncoding RNAs in the human transcriptome. Nat Genet. (2015);47(3):199-208.

4. Schmitt AM, Chang HY. Long Noncoding RNAs in Cancer Pathways. Cancer Cell. (2016);29(4):452-463.

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