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The inflammasome signaling pathway a central component of innate immunity that detects pathogen-associated molecular patterns (PAMPs) and danger-associated molecular patterns (DAMPs) generated during infection, tissue damage, or cellular stress.
Inflammasomes are cytosolic multiprotein complexes that activate inflammatory responses by activating multiprotein complexes known as inflammasomes, which trigger cytokine maturation and inflammatory cell death.
Among the different inflammasome complexes, the NLRP3 inflammasome is the most extensively studied due to its involvement in numerous inflammatory and metabolic diseases.
Under physiological conditions, inflammasome signaling contributes to host defense and immune surveillance. Under pathological conditions, however, excessive or chronic inflammasome activation can drive persistent inflammation and tissue damage.
Inflammasome signaling pathway activity can be efficiently assessed through transcriptional profiling of inflammasome sensors, cytokines, and pyroptosis-related genes, allowing researchers to characterize inflammatory activation states and immune responses.
Inflammasome signaling pathway biomarker list
View the genes included in our inflammasome-related qPCR arrays.
The inflammasome signaling pathway is composed of several key molecular elements:
Inflammasome activation generally requires two sequential signals:
Priming signal
Triggered by PAMPs or DAMPs via Toll-like receptors, leading to NF-κB-dependent transcription of inflammasome components such as NLRP3, CASP1, IL1B and IL18.
Activation signal
Induced by cellular stress signals such as potassium efflux, mitochondrial dysfunction, ROS, ATP, or lysosomal damage.
This process involves four major steps:
Inflammasome activation regulates key immune and inflammatory processes:
Inflammasome signaling operates within a broader inflammatory network and interacts with multiple signaling pathways.
Key interactions include:
In inflammatory diseases and cancer, these interconnected pathways collectively shape immune responses and tissue remodeling.
Dysregulated inflammasome signaling contributes to numerous diseases:
Inflammasome signaling is a major therapeutic target:
Accurate biomarker profiling is critical to guide therapeutic strategies.
At AnyGenes®, we provide high-performance qPCR arrays and customizable SignArrays® dedicated to inflammasome signaling and inflammation research.
Our solutions enable researchers to:
Generate reproducible, publication-ready data
What can be analyzed?
Scientific data is only as powerful as the analysis behind it.
AnyGenes® provides a dedicated data analysis tool specifically developed for SignArrays® pathway panels.
What does it allow you to do?
Developed on Excel (compatible with 2007+), the software is user-friendly and requires no advanced bioinformatics skills.
Customize your own signaling pathways (SignArrays®) with the factors of your choice!
Simply download and complete our Personalized SignArrays® information file
and send it at
[email protected]
to initiate your project.
It is an innate immune pathway that activates inflammatory cytokines and pyroptotic cell death in response to infection or cellular stress.
NLRP3 is a sensor protein that detects diverse danger signals and triggers caspase-1 activation.
NF-κB provides the priming signal required for inflammasome activation by inducing gene expression.
By measuring expression of inflammasome components and cytokines using targeted gene expression approaches such as qPCR arrays.
| Signaling Pathways | Product ref | Informations |
|---|---|---|
Inflammasome Signaling Pathway | IFS1H1 |
| Signaling Pathways | Product ref | Informations |
|---|---|---|
Inflammasome Signaling Pathway | ******* |
Biomarker list in progress. |
| Signaling Pathways | Product ref | Informations |
|---|---|---|
Inflammasome Signaling Pathway | ******* |
Biomarker list in progress. |
| Signaling Pathways | Product ref | Informations |
|---|---|---|
Inflammasome Signaling Pathway | ******* |
Biomarker list in progress. |
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1. Sharma BR, Kanneganti TD. NLRP3 inflammasome in cancer and metabolic diseases. Nat Immunol. (2021);22(5):550-559.
2. Paik S et al. An update on the regulatory mechanisms of NLRP3 inflammasome activation. Cell Mol Immunol. (2021);18(5):1141-1160.
3. Wang L, Hauenstein AV. The NLRP3 inflammasome: Mechanism of action, role in disease and therapies. Mol Aspects Med. (2020);76:100889.
4. Zhao N, Di B, Xu LL. The NLRP3 inflammasome and COVID-19: Activation, pathogenesis and therapeutic strategies. Cytokine Growth Factor Rev. (2021);61:2-15.
5. Zhao C, Zhao W. NLRP3 Inflammasome-A Key Player in Antiviral Responses. Front Immunol. (2020)18;11:211..