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The inflammasome signaling pathway is a core component of the innate immune system that detects microbial infections, cellular stress, and tissue damage. It coordinates inflammatory responses by activating multiprotein complexes known as inflammasomes, which trigger cytokine maturation and inflammatory cell death.
Among these complexes, the NLRP3 inflammasome is the most extensively studied. Upon activation, inflammasomes recruit adaptor proteins and caspase-1, leading to the maturation and secretion of pro-inflammatory cytokines IL-1β and IL-18, and induction of pyroptosis.
Dysregulated inflammasome signaling is a key driver of chronic inflammation and immune-mediated diseases.
Inflammasome signaling pathway biomarker list
View the genes included in our inflammasome-related qPCR arrays.
The inflammasome signaling pathway is composed of several key molecular elements:
Inflammasome activation generally requires two sequential signals:
Priming signal
Triggered by PAMPs or DAMPs via Toll-like receptors, leading to NF-κB-dependent transcription of inflammasome components such as NLRP3, CASP1, IL1B and IL18.
Activation signal
Induced by cellular stress signals such as potassium efflux, mitochondrial dysfunction, ROS, ATP, or lysosomal damage.
This process involves four major steps:
Inflammasome activation regulates key immune and inflammatory processes:
Dysregulated inflammasome signaling contributes to numerous diseases:
Inflammatory and autoimmune diseases
Metabolic disorders
Neurodegenerative diseases
Cardiovascular diseases
Infectious diseases : Severe viral infections, including COVID-19
Inflammasome signaling is a major therapeutic target:
Accurate biomarker profiling is critical to guide therapeutic strategies.
At AnyGenes®, we provide high-performance qPCR arrays and customizable SignArrays® dedicated to inflammasome signaling and inflammation research.
Our solutions enable researchers to:
Generate reproducible, publication-ready data
What can be analyzed?
Customize your own signaling pathways (SignArrays®) with the factors of your choice!
Simply download and complete our Personalized SignArrays® information file and send it at [email protected] to initiate your project.
It is an innate immune pathway that activates inflammatory cytokines and pyroptotic cell death in response to infection or cellular stress.
NLRP3 is a sensor protein that detects diverse danger signals and triggers caspase-1 activation.
NF-κB provides the priming signal required for inflammasome activation by inducing gene expression.
By measuring expression of inflammasome components and cytokines using targeted gene expression approaches such as qPCR arrays.
Through targeted qPCR arrays or customized SignArrays® optimized for MAPK pathway biomarker analysis.
| Signaling Pathways | Product ref | Informations |
|---|---|---|
Inflammasome Signaling Pathway | IFS1H1 |
| Signaling Pathways | Product ref | Informations |
|---|---|---|
Inflammasome Signaling Pathway | ******* |
| Signaling Pathways | Product ref | Informations |
|---|---|---|
Inflammasome Signaling Pathway | ******* |
| Signaling Pathways | Product ref | Informations |
|---|---|---|
Inflammasome Signaling Pathway | ******* |
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