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The HIF-1 pathway is a central oxygen-sensing signaling mechanism that regulates cellular adaptation to hypoxia.
Hypoxia-Inducible Factor 1 (HIF-1) is a transcription factor composed of two subunits:
The HIF-1 pathway regulates:
Dysregulation of HIF-1 signaling is strongly associated with cancer progression, ischemic diseases, chronic inflammation, and therapy resistance.
HIF-1 signaling activity can be efficiently assessed by measuring expression of HIF-1 target genes and downstream transcriptional signatures.
HIF-1 signaling biomarker list
View the genes included in our HIF-1 qPCR arrays.
Under normal oxygen levels:
Under hypoxia:
HIF-1 induces expression of:
These factors promote vascular remodeling and oxygen delivery, particularly in tumors.
HIF-1 drives a metabolic switch toward glycolysis by upregulating:
This shift enables ATP production independent of oxidative phosphorylation and supports tumor survival.
The HIF-1 transcriptional program drives a metabolic switch toward glycolysis by upregulating:
These interactions amplify survival signals and contribute to therapeutic resistance.
Tumor hypoxia activates HIF-dependent transcription, promoting:
HIF-1α overexpression is correlated with poor prognosis in multiple cancer types.
Ischemic diseases
HIF-1 regulates protective responses following myocardial infarction or stroke.
Chronic inflammatory disorders
Hypoxia-driven HIF activation modulates immune cell metabolism and inflammatory signaling.
Metabolic disorders
HIF-1 influences glucose metabolism and insulin sensitivity.
Because of its central role in tumor adaptation, the HIF-1 is an emerging therapeutic target.
Current strategies include:
Accurate biomarker profiling of HIF-1 activity is essential for patient stratification and treatment monitoring.
At AnyGenes®, we provide high-performance qPCR arrays and customizable SignArrays® dedicated to hypoxia and HIF analysis.
Our solutions allow researchers to:
Customize your own signaling pathways (SignArrays®) with the factors of your choice!
Simply download and complete our Personalized SignArrays® information file and send it at [email protected] to get started on your project.
The HIF-1 pathway is an oxygen-sensitive signaling mechanism that regulates gene expression under hypoxic conditions through stabilization of HIF-1α and activation of hypoxia-responsive genes.
Under low oxygen levels, HIF-1α stabilizes, dimerizes with HIF-1β, and activates transcription of genes involved in angiogenesis, metabolism, and survival.
Tumor hypoxia activates HIF-1 signaling, promoting angiogenesis, metabolic adaptation, immune evasion, metastasis, and resistance to therapy.
Key target genes include VEGFA, EPO, GLUT1, LDHA, and PDK1, which support vascularization and metabolic adaptation.
HIF-1 activity can be measured by assessing gene expression of HIF-1α, angiogenic factors, and glycolytic enzymes using targeted gene expression tools such as qPCR pathway arrays.
| Signaling Pathways | Product ref | Informations |
|---|---|---|
HIF-1 Signaling Pathway | HIF1H1 |
| Signaling Pathways | Product ref | Informations |
|---|---|---|
HIF-1 Signaling Pathway | HIF1M1 |
| Signaling Pathways | Product ref | Informations |
|---|---|---|
HIF-1 Signaling Pathway | ******* |
| Signaling Pathways | Product ref | Informations |
|---|---|---|
HIF-1 Signaling Pathway | ******* |
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