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The HIF-1 pathway is a central oxygen-sensing signaling mechanism that regulates cellular adaptation to hypoxia.
Hypoxia-Inducible Factor 1 (HIF-1) is a transcription factor composed of two subunits:
The HIF-1 pathway regulates:
Dysregulation of HIF-1 signaling is strongly associated with cancer progression, ischemic diseases, chronic inflammation, and therapy resistance.
HIF-1 signaling activity can be efficiently assessed by measuring expression of HIF-1 target genes and downstream transcriptional signatures.
HIF-1 signaling biomarker list
View the genes included in our HIF-1 qPCR arrays.
Under normal oxygen levels:
Under hypoxia:
The HIF-1 transcriptional program drives a metabolic switch toward glycolysis by upregulating:
These interactions amplify survival signals and contribute to therapeutic resistance.
HIF-1 induces expression of:
These factors promote vascular remodeling and oxygen delivery, particularly in tumors.
HIF-1 drives a metabolic switch toward glycolysis by upregulating:
This shift enables ATP production independent of oxidative phosphorylation and supports tumor survival.
Tumor hypoxia activates HIF-dependent transcription, promoting:
HIF-1α overexpression is correlated with poor prognosis in multiple cancer types.
Ischemic diseases
HIF-1 regulates protective responses following myocardial infarction or stroke.
Chronic inflammatory disorders
Hypoxia-driven HIF activation modulates immune cell metabolism and inflammatory signaling.
Metabolic disorders
HIF-1 influences glucose metabolism and insulin sensitivity.
Because of its central role in tumor adaptation, the HIF-1 is an emerging therapeutic target.
Current strategies include:
Accurate biomarker profiling of HIF-1 activity is essential for patient stratification and treatment monitoring.
At AnyGenes®, we provide high-performance qPCR arrays and customizable SignArrays® dedicated to hypoxia and HIF analysis.
Our solutions allow researchers to:
Scientific data is only as powerful as the analysis behind it.
AnyGenes® provides a dedicated data analysis tool specifically developed for SignArrays® pathway panels.
What does it allow you to do?
Developed on Excel (compatible with 2007+), the software is user-friendly and requires no advanced bioinformatics skills.
Customize your own signaling pathways (SignArrays®) with the factors of your choice!
Simply download and complete our Personalized SignArrays® information file
and send it at
[email protected]
to initiate your project.
The HIF-1 pathway is an oxygen-sensitive signaling mechanism that regulates gene expression under hypoxic conditions through stabilization of HIF-1α and activation of hypoxia-responsive genes.
Under low oxygen levels, HIF-1α stabilizes, dimerizes with HIF-1β, and activates transcription of genes involved in angiogenesis, metabolism, and survival
Tumor hypoxia activates HIF-1 signaling, promoting angiogenesis, metabolic adaptation, immune evasion, metastasis, and resistance to therapy
Key target genes include VEGFA, EPO, GLUT1, LDHA, and PDK1, which support vascularization and metabolic adaptation.
HIF-1 activity can be measured by assessing gene expression of HIF-1α, angiogenic factors, and glycolytic enzymes using targeted gene expression tools such as qPCR pathway arrays;
| Signaling Pathways | Product ref | Informations |
|---|---|---|
HIF-1 Signaling Pathway | HIF1H1 |
| Signaling Pathways | Product ref | Informations |
|---|---|---|
HIF-1 Signaling Pathway | HIF1M1 |
| Signaling Pathways | Product ref | Informations |
|---|---|---|
HIF-1 Signaling Pathway | ******* |
Biomarker list in progress. |
| Signaling Pathways | Product ref | Informations |
|---|---|---|
HIF-1 Signaling Pathway | ******* |
Biomarker list in progress. |
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2. Jin Q et al. Hypoxia-inducible factor-1 signaling pathway influences the sensitivity of HCC827 cells to gefitinib. Oncol Lett. (2019);17(4):4034-4043.
3. Li H et al. Targeting HIF-1α signaling pathway for gastric cancer treatment. Pharmazie.(2019);74(1):3-7.
4. Qin Y et al. Salidroside improves the hypoxic tumor microenvironment and reverses the drug resistance of platinum drugs via HIF-1α signaling pathway. EBioMedicine. (2018);38:25-36.
5. Huang Y et al. Hypoxia inducible factor (HIF) in the tumor microenvironment: friend or foe? Sci China Life Sci. (2017);60(10):1114-1124.
6. Lee HJ et al. Role of HIF1α Regulatory Factors in Stem Cells. Int J Stem Cells. (2019 );12(1):8-20.
7. Xia Y et al. The role of HIF-1α in chemo-/radioresistant tumors. Onco Targets Ther. (2018); 11: 3003–3011.