Logout
If you want to log out click in LogOut
The angiogenesis pathway is a tightly regulated biological process responsible for the formation of new blood vessels from pre-existing vasculature. This signaling network is essential for tissue growth, wound healing, embryonic development, and physiological vascular remodeling.
Under pathological conditions, dysregulated angiogenesis contributes to tumor progression, chronic inflammation, ischemic disorders, and vascular diseases.
The angiogenesis pathway integrates multiple growth factors, endothelial signaling cascades, extracellular matrix remodeling enzymes, and perivascular cell recruitment mechanisms to coordinate vascular sprouting and maturation.
Angiogenesis pathway activity can be efficiently assessed by measuring gene expression of pro-angiogenic factors, vascular regulators, and downstream signaling biomarkers.
Angiogenesis pathway biomarker list
View the genes included in our angiogenesis-related qPCR arrays.
Key angiogenic biomarkers include:
These markers reflect endothelial activation, matrix remodeling, and vessel maturation.
Sprouting angiogenesis is initiated when endothelial cells respond to angiogenic signals such as VEGF.
Key steps include:
This mechanism is predominant in tumor vascularization and wound repair.
Intussusceptive (splitting) angiogenesis occurs when existing vessels divide through the formation of intraluminal tissue pillars.
This mechanism:
VEGF is the primary pro-angiogenic driver.
VEGF binding to VEGFR-1 and VEGFR-2 activates:
VEGF signaling is a major therapeutic target in oncology.
PDGF regulates vessel maturation by recruiting pericytes and stabilizing newly formed vessels.
It ensures vascular integrity and structural organization.
FGF2 stimulates endothelial proliferation and plays a role in tissue repair and regenerative angiogenesis.
Tumors exploit the angiogenesis pathway to sustain growth and metastasis.
Tumor hypoxia induces VEGF production, leading to:
Anti-angiogenic therapies aim to disrupt this vascular supply.
Angiogenesis biomarkers are used to:
Common anti-angiogenic strategies include:
At AnyGenes®, we provide high-performance qPCR arrays and customizable SignArrays® dedicated to angiogenesis pathway analysis.
Our solutions enable researchers to:
Generate robust, reproducible, publication-ready data
What can be analyzed?
Customize your own signaling pathways (SignArrays®) with the factors of your choice!
Simply download and complete our Personalized SignArrays® information file and send it at [email protected] to get started on your project.
The angiogenesis pathway is a molecular signaling network that regulates the formation of new blood vessels from existing vasculature through coordinated activation of endothelial cells and growth factor signaling.
Angiogenesis is primarily triggered by hypoxia and growth factors such as VEGF, FGF, and PDGF, which stimulate endothelial cell migration, proliferation, and survival.
Tumors activate the angiogenesis pathway to secure oxygen and nutrient supply, promoting tumor growth, metastasis, and resistance to therapy.
Key biomarkers include VEGFA, VEGFR2, FGF2, PDGFB, ANGPT2, MMPs, and endothelial markers such as CD31.
Angiogenesis pathway activity can be analyzed by measuring expression of angiogenic growth factors, receptors, and downstream signaling genes using targeted gene expression tools such as qPCR pathway arrays.
| Signaling Pathways | Product ref | Informations |
|---|---|---|
Angiogenesis | AN1H1 | |
Angiogenesis | AN2H1 |
| Signaling Pathways | Product ref | Informations |
|---|---|---|
Angiogenesis | AN1M1 | |
Angiogenesis | AN2M1 |
| Signaling Pathways | Product ref | Informations |
|---|---|---|
Angiogenesis | ******* |
| Signaling Pathways | Product ref | Informations |
|---|---|---|
Angiogenesis | ******* |
Looking for more answers? Visit our Help & FAQ section to find detailed informations about our products, services, and technical support.
For more information on prices, please contact us at: