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The Wnt beta Catenin signaling pathway (also referred to as Wnt/β-Catenin signaling pathway) is a highly conserved molecular signaling cascade that regulates cell proliferation, differentiation, migration, and survival.
It plays a fundamental role in embryonic development, tissue homeostasis, and regeneration, and remains tightly controlled in adult tissues.
In the canonical Wnt pathway, extracellular Wnt ligands trigger intracellular signaling events that stabilize β-catenin, allowing it to translocate into the nucleus and activate transcriptional programs controlling cell fate and metabolism.
Dysregulation of Wnt/β-catenin signaling is strongly associated with cancer, fibrosis, metabolic disorders, and stem cell dysfunction.
Wnt/β-catenin pathway activity can be efficiently assessed by measuring gene expression of core regulators, downstream targets, and pathway-specific biomarker signatures.
Wnt/β-catenin signaling pathway biomarker list
View the genes included in our TGF-β pathway qPCR arrays.
Canonical Wnt signaling is initiated when Wnt ligands bind to Frizzled receptors and co-receptors LRP5/6 at the cell surface. This interaction inhibits the β-catenin destruction complex, allowing β-catenin accumulation in the cytoplasm.
Once stabilized, β-catenin translocates to the nucleus, where it interacts with TCF/LEF transcription factors to activate genes involved in:
Core molecular components
• Wnt ligands – extracellular signaling proteins
• Frizzled receptors & LRP5/6 – signal reception at the membrane
• β-catenin – central transcriptional effector
• Destruction complex (APC, AXIN, GSK-3β, CK1) – regulates β-catenin degradation in the absence of Wnt signaling
The pathway operates through a tightly regulated ON / OFF switch:
OFF state
β-catenin is continuously phosphorylated and degraded by the destruction complex, preventing transcriptional activation.
ON state
Wnt ligand binding inactivates the destruction complex, allowing β-catenin stabilization and nuclear signaling.
This dynamic balance ensures accurate cellular responses to environmental and developmental cues.
Aberrant activation or suppression of Wnt/β-catenin signaling contributes to numerous pathological conditions:
Cancer: Hyperactivation promotes uncontrolled proliferation, tumor initiation, progression, and therapeutic resistance
(Common in colorectal, breast, pancreatic and liver cancers).
Fibrosis: Sustained signaling drives fibroblast activation and extracellular matrix deposition
Bone disorders: Impaired signaling alters bone remodeling and density, contributing to osteoporosis.
Neurological diseases: Dysregulation affects neurogenesis and synaptic plasticity, linked to neurodegenerative disorders.
Metabolic diseases: Altered Wnt/β-catenin activity disrupts adipogenesis, glucose metabolism and energy balance.
The Wnt/β-catenin signaling pathway interacts extensively with other major signaling networks:
This crosstalk highlights the pathway’s central role in complex biological systems.
At AnyGenes®, we provide high-performance qPCR arrays and customizable SignArrays® dedicated to Wnt/β-catenin pathway analysis.
Our solutions enable researchers to:
What can be analyzed?
Customize your own signaling pathways (SignArrays®) with the factors of your choice!
Simply download and complete our Personalized SignArrays® information file and send it at [email protected] to get started on your project.
It is activated by Wnt ligands binding to Frizzled and LRP5/6 receptors, leading to β-catenin stabilization and nuclear transcriptional activation.
Its dysregulation promotes uncontrolled proliferation, stemness, metastasis and therapy resistance.
Key genes include CTNNB1 (β-catenin), APC, AXIN1/2, GSK3B, LRP5/6, TCF7 and LEF1.
By measuring expression of pathway regulators and downstream targets using targeted gene expression approaches such as qPCR pathway arrays.
| Signaling Pathways | Product ref | Informations |
|---|---|---|
Wntβ-catenin Signaling Pathway | WNTB1H1 |
| Signaling Pathways | Product ref | Informations |
|---|---|---|
Wntβ-catenin Signaling Pathway | WNTB1M1 |
| Signaling Pathways | Product ref | Informations |
|---|---|---|
Wntβ-catenin Signaling Pathway | ******* |
| Signaling Pathways | Product ref | Informations |
|---|---|---|
Wntβ-catenin Signaling Pathway | ******* |
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