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The NF-κB signaling pathway (nuclear factor kappa-light-chain-enhancer of activated B cells pathway) is a central regulatory pathway controlling immune response, inflammation, cell survival, and stress adaptation.
NF-κB signaling is activated by a wide range of stimuli, including pro-inflammatory cytokines, microbial infections, oxidative stress, and cellular damage. Once activated, NF-κB transcription factors translocate to the nucleus and regulate the expression of genes involved in immune defense, inflammation, apoptosis, and cell proliferation.
Dysregulation of NF-κB signaling is strongly associated with chronic inflammatory diseases, cancer, cardiovascular disorders, and neurodegenerative conditions, making it one of the most intensively studied signaling pathways in biomedical research.
NF-κB pathway activity can be efficiently assessed through targeted gene expression analysis of pathway regulators and downstream transcriptional targets.
NF-κB signaling pathway biomarker list
View the genes and molecular targets included in our NF-κB pathway qPCR arrays.
NF-κB exists as homo- or heterodimers composed of RelA (p65), RelB, c-Rel, p50, and p52 subunits.
IκB proteins sequester NF-κB dimers in the cytoplasm and prevent nuclear translocation under resting conditions.
The IκB kinase (IKK) complex, composed of IKKα, IKKβ, and IKKγ/NEMO, phosphorylates IκB proteins, targeting them for proteasomal degradation.
Upon IκB degradation, NF-κB dimers translocate to the nucleus and activate gene transcription.
NF-κB signaling interacts extensively with other signaling networks:
This cross-talk adds regulatory complexity and expands the range of NF-κB-dependent biological outcomes.
Given its central role in disease, NF-κB is a major therapeutic target:
Chronic inflammatory diseases
Persistent NF-κB activation contributes to:
Cancer
Constitutive NF-κB signaling promotes:
Cardiovascular and neurodegenerative disorders
NF-κB dysregulation is implicated in:
What can be analyzed?
Available solutions
Scientific data is only as powerful as the analysis behind it.
AnyGenes® provides a dedicated data analysis tool specifically developed for SignArrays® pathway panels.
What does it allow you to do?
Developed on Excel (compatible with 2007+), the software is user-friendly and requires no advanced bioinformatics skills.
Customize your own signaling pathways (SignArrays®) with the factors of your choice!
Simply download and complete our Personalized SignArrays® information file
and send it at
[email protected]
to initiate your project.
NF-κB signaling regulates inflammation, immune responses, cell survival, and stress adaptation by controlling the expression of numerous target genes.
NF-κB is activated by cytokines, microbial products, oxidative stress, and cellular damage signals.
NF-κB dysregulation is linked to chronic inflammatory diseases, cancer, cardiovascular disorders, and neurodegenerative diseases.
The canonical pathway mediates rapid inflammatory responses, while the non-canonical pathway regulates adaptive immunity and lymphoid development.
NF-κB activity can be analyzed by measuring the expression of pathway regulators and downstream target genes using targeted qPCR pathway arrays.
| Signaling Pathways | Product ref | Informations |
|---|---|---|
NFKB Signaling Pathway | NFKB1H1 |
| Signaling Pathways | Product ref | Informations |
|---|---|---|
NFKB Signaling Pathway | NFKB1M1 |
| Signaling Pathways | Product ref | Informations |
|---|---|---|
NFKB Signaling Pathway | ******* |
Biomarker list in progress. |
| Signaling Pathways | Product ref | Informations |
|---|---|---|
NFKB Signaling Pathway | ******* |
Biomarker list in progress. |
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1. Wang Y, et al. NF-κB signaling in skin aging. Mech Ageing Dev. (2019);184:111160.
2. Soleimani A, et al. Role of the NF-κB signaling pathway in the pathogenesis of colorectal cancer. Gene. (2020);726:144132..
3. Ramadass V, et al. Small Molecule NF-κB Pathway Inhibitors in Clinic. Int J Mol Sci. (2020);21(14):5164..
4. Singh S, & Singh TG. Role of Nuclear Factor Kappa B (NF-κB) Signalling in Neurodegenerative Diseases: An Mechanistic Approach. Curr Neuropharmacol. (2020);18(10):918-935.