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WNT/β-CATENIN SIGNALING PATHWAY

The Wnt/β-Catenin signaling pathway (also referred to as Wnt beta Catenin signaling pathway) is a highly conserved molecular mechanism regulating cell proliferation, differentiation, migration, and survival. It plays a pivotal role in embryonic development, tissue regeneration, and homeostasis.

At AnyGenes, we provide advanced qPCR arrays tailored for Wnt/β-Catenin signaling research, enabling precise biomarker analysis and deeper understanding of its regulatory networks.

AnyGenes Wnt/β-Catenin signaling pathway qPCR array for precise gene expression analysis.

Discover our advanced qPCR arrays for Wnt/β Catenin Signaling research.

Illustration of Wnt/β-catenin signaling pathway in cell signaling
Wnt/β-Catenin Signaling: The Culprit in Pancreatic Carcinogenesis and Therapeutic Resistance.

KEY MECHANISMS OF WNT/β-CATENIN SIGNALING

Wnt signaling begins when Wnt ligands bind to Frizzled receptors and co-receptors (LRP5/6) at the cell surface. This inhibits destruction of complex, allowing β-catenin to stabilize, accumulate and translocate into the nucleus.

Inside the nucleus, β-catenin interacts with transcription factors (TCF/LEF), activating target genes involved in cell growth, survival and tissue maintenance.

Core Components Include:

  • Wnt ligands: trigger signaling pathways by binding to receptors.
  • Frizzled receptors: mediate Wnt signaling at the membrane.
  • β-Catenin: central effector regulating gene transcription.
  • Destruction complex (APC, Axin, GSK-3β, CK1):  degrades β-catenin in the absence of Wnt signals.

WNT/β CATENIN SIGNALING PATHWAY IN DISEASES

Abnormal regulation of the Wnt/β-Catenin pathway contributes to several pathological conditions:

  • Cancer: hyperactivation drives uncontrolled cell proliferation (exemple: colorectal, breast and pancreatic cancer).
  • Fibrosis: overactivation leads to tissue scarring in the liver, lungs, and kidneys.
  • Bone disorders: impaired signaling affects bone density remodling, linked to osteoporosis.
  • Neurological diseases: dysregulation impacts neurogenesis and synaptic function, implicated in Alzheimer’s and Parkinson’s.
  • Obesity and diabetes: altered Wnt/β-catenin activity disrupts metabolic balance.

DYNAMIC REGULATION OF WNT SIGNALING

The Wnt/β-Catenin signaling pathway is tightly controled by feedback mechanisms:

  • “Off” state: the destruction complex degrades β-catenin, preventing nuclear translocation.
  • “On” state: Wnt binding inactivates the destruction complex, stabilizing β-Catenin, which then regulates transcription.

This balance ensures accurate cellular responses to environmental signals.

CROSSTALK WITH OTHER SIGNALING PATHWAYS

The Wnt/β-Catenin signaling pathway interacts with multiple signaling networks, shaping complex biological responses :

  • Wnt & Notch pathway: coordinate stem cell maintenance and tissue regeneration.
  • Wnt & TGF-β/Smad: drive fibrosis and cancer progression through synergistic activation.
  • Wnt & PI3K-Akt: enhance cell survival and resistance to stress and apoptosis.
  • Wnt & Hedgehog: collaborate in embryonic development and organogenesis.
Aberrant Wnt/β-catenin signaling in cancer cells
Wnt/β-Catenin Signaling: The Culprit in Pancreatic Carcinogenesis and Therapeutic Resistance.

FREQUENTLY ASKED QUESTIONS

The pathway is activated by Wnt ligands binding to Frizzled and LRP5/6 receptors, leading to β-catenin stabilization and nuclear translocation, where it regulates gene expression.

Key genes include WNT ligands, FZD receptors, LRP5/6, CTNNB1 (β-catenin), APC, AXIN, GSK3β, and transcription factors like TCF/LEF.

Aberrant activation promotes uncontrolled cell growth, stemness, and metastasis, making it a critical target for cancer research.

You can customize your own SignArrays® by downloading and completing our Personalized SignArrays® information file. Send it to [email protected] to get started on your project.

  1. Haseeb M et al. Wnt Signaling in the Regulation of Immune Cell and Cancer Therapeutics. Cells. (2019)3;8(11).
  2. Lecarpentier Y et al. Multiple Targets of the Canonical WNT/β-Catenin Signaling in Cancers. Front Oncol. (2019)18;9:1248.
  3. Zhong Z et Virshup DM. Wnt signaling and drug resistance in cancer. Mol Pharmacol. (2019)1.
  4.  Mo Y et al. The role of Wnt signaling pathway in tumor metabolic reprogramming. J Cancer. (2019)9;10(16):3789-3797.
  5. Ram Makena M et al. Wnt/β-Catenin Signaling: The Culprit in Pancreatic Carcinogenesis and Therapeutic Resistance. Int J Mol Sci. (2019)30;20(17).
  6. Ng LF et al. WNT Signaling in Disease. Cells. (2019)3;8(8).

WNT beta CATENIN SIGNALING PATHWAY BIOMARKER LIST

Customize your own signaling pathways (SignArrays®) with the factors of your choice!
Simply download and complete our Personalized SignArrays® information file and send it at [email protected] to get started on your project.

You can check the biomarker list included in this pathway, see below:

Species : Homo sapiens (human)

Human Signaling Pathways

Signaling PathwaysProduct refInformations

Wntβ-catenin Signaling Pathway

WNTB1H1

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Species : Mus musculus (mouse)

Mouse Signaling Pathway

Signaling PathwaysProduct refInformations

Wntβ-catenin Signaling Pathway

WNTB1M1

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Species : Rattus norvegicus (rat)

Rat Signaling Pathways

Signaling PathwaysProduct refInformations

Wntβ-catenin Signaling Pathway

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Species : Sus Scrofa (Pig)

Pig Signaling Pathways

Signaling PathwaysProduct refInformations

Wntβ-catenin Signaling Pathway

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List In progress...


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