Hi, Continue visiting your profile
user

Login

Email

Password

Create account
Forget password
AnyGenes
  • email login

PI3K/AKT SIGNALING PATHWAY, KEY REGULATOR OF CELL GROWTH AND SURVIVAL

The PI3K/Akt signaling pathway is a central regulator of essential cellular processes such as proliferation, angiogenesis, cell growth, survival, metabolism, and motility. It is activated by a variety of extracellular signals, including growth factors, hormones, and nutrients. Once activated, the phosphoinositide 3-kinase (PI3K) catalyzes the production of PIP3, which in turn activates the serine/threonine kinase Akt. This activation triggers a cascade of downstream effects crucial for cell survival and proliferation.

AnyGenes offers high-quality qPCR arrays specifically designed to analyze the expression of genes involved in the PI3K-Akt signaling pathway. These solutions enable researchers to perform detailed studies on the pathway’s role in various physiological and pathological conditions, contributing to the development of targeted therapies and disease understanding.

AnyGenes PI3K/Akt signaling pathway qPCR array for advanced cellular signaling research.

Discover key genes driving the PI3K/Akt Signaling Pathway with our qPCR arrays.

PI3K/Akt-signaling-pathway
Upstream activation of the PI3K/Akt signaling pathway.

KEY COMPONENTS OF THE PI3K/AKT SIGNALING PATHWAY

  • PI3K: initiates the pathway by converting PIP2 to PIP3, a second messenger that activates Akt.
  • Akt (Protein Kinase B): central kinase transmitting signals downstream to regulate key processes like metabolism, cell cycle progression, and anti-apoptosis.
  • mTOR (Mechanistic Target of Rapamycin): activated by Akt, mTOR controls protein synthesis and cell growth, linking the pathway to metabolic processes.
  • PTEN (Phosphatase and Tensin Homolog): negative regulator
    dephosphorylates PIP3, counteracting PI3K activation.

BIOLOGICAL ROLES OF THE PI3K/AKT SIGNALING PATHWAY

  • Cell growth and proliferation: essential for cellular expansion and division, particularly in response to growth factor stimulation.
  • Cell survival: Akt activates various anti-apoptotic proteins, helping cells survive under stress conditions.
  • Metabolism Regulation: controls glucose metabolism and lipid synthesis.
  • Angiogenesis: supports blood vessel formation, crucial for tissue repair and tumor growth.

PI3K/AKT PATHWAY IN CANCER AND OTHER DISEASES

The PI3K/Akt signaling pathway is often dysregulated in :

  • Cancer: overactivation contributes to uncontrolled cell growth, resistance to cell death, and metastasis.
  • Diabetes: impaired insulin signaling can lead to insulin resistance and metabolic disorders.
  • Neurodegenerative diseases: linked to Alzheimer’s, Parkinson’s, and other disorders.
  • Cardiovascular diseases: dysregulation affects cardiac function, potentially causing heart failure and atherosclerosis.

THERAPEUTIC TARGETING OF THE PI3K-AKT PATHWAY

Because its central role in many diseases, the PI3K/Akt pathway is a major therapeutic target.

  • Cancer: PI3K, Akt, and mTOR inhibitors are in development to suppress tumor growth and overcome resistance.
  • Metabolic disorders: modulation of this pathway is explored for diabetes and obesity treatments.
  • Neurodegenerative & cardiovascular diseases: restoring PI3K/Akt balance can promote tissue repair and cell protection.

FREQUENTLY ASKED QUESTIONS

The pathway is activated by growth factors binding to RTKs, PI3K produces PIP3, and AKT phosphorylates downstream proteins to regulate cell survival, growth, metabolism, and angiogenesis.

The pathway involves multiple genes: PIK3CA, AKT1/2/3, PTEN, and downstream effectors like mTOR. Studying these genes clarifies the pathway’s role in health and disease.

PI3K/AKT interacts with NF-κB, enhancing its activity to promote cell survival, inflammation, and therapy resistance.

Activated AKT phosphorylates pro-apoptotic proteins like BAD and caspase-9, while increasing survival proteins such as Bcl-2, preventing programmed cell death.

You can explore our curated list of PI3K/AKT biomarkers in the table below to check if they align with your research objectives. If your genes of interest are not listed, you can customize your own SignArrays® by downloading and completing our Personalized SignArrays® information file. Send it to  [email protected]  to get started on your project.
  1. Jafari M et al. PI3k/AKT signaling pathway: Erythropoiesis and beyond. J Cell Physiol. (2019);234(3):2373-2385.
  2. He Y et al. Targeting PI3K/Akt signal transduction for cancer therapy. Signal Transduct Target Ther. (2021);6(1):425.
  3. Liu R et al. PI3K/AKT pathway as a key link modulates the multidrug resistance of cancers. Cell Death Dis. (2020);11(9):797.
  4. Teng Y et al. The PI3K/Akt Pathway: Emerging Roles in Skin Homeostasis and a Group of Non-Malignant Skin Disorders. Cells. (2021);10(5):1219.
  5. Chu E et al. Dysregulated phosphoinositide 3-kinase signaling in microglia: shaping chronic neuroinflammation. J Neuroinflammation. (2021);18(1):276.

PI3K-AKT SIGNALING PATHWAY BIOMARKER LIST

Customize your own signaling pathways (SignArrays®) with the factors of your choice!
Simply download and complete our Personalized SignArrays® information file and send it at [email protected] to get started on your project.

You can check the biomarker list included in this pathway, see below:

Species : Homo sapiens (human)

Human Signaling Pathways

Signaling PathwaysProduct refInformations

PI3K-AKT Signaling Pathway

AKT1H1

List infos


Species : Mus musculus (mouse)

Mouse Signaling Pathways

Signaling PathwaysProduct refInformations

PI3K-AKT Signaling Pathway

AKT1M1

List infos


Species : Rattus norvegicus (rat)

Rat Signaling Pathways

Signaling PathwaysProduct refInformations

PI3K-AKT Signaling Pathway

*******

List In progress...


Species : Sus Scrofa (Pig)

Pig Signaling Pathways

Signaling PathwaysProduct refInformations

PI3K-AKT Signaling Pathway

*******

List In progress...


Looking for more answers? Visit our Help & FAQ section to find detailed informations about our products, services, and technical support.

For more information on prices, please contact us at:

[email protected]