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Oxidative stress signaling pathways describe the cellular mechanisms activated in response to an imbalance between reactive oxygen species (ROS) production and antioxidant defenses.
At physiological levels, ROS act as signaling molecules regulating cell proliferation, immune responses, and metabolic adaptation. When ROS levels exceed antioxidant capacity, oxidative stress triggers signaling cascades that alter gene expression, inflammation, and cell fate.
Dysregulation of oxidative stress signaling pathways contributes to cancer, neurodegenerative diseases, cardiovascular disorders, metabolic syndromes, and aging.
Oxidative stress signaling pathway activity can be efficiently assessed by measuring gene expression of redox regulators, downstream targets, and pathway-specific biomarker signatures.
Oxidative stress biomarker list
View the genes included in our Oxidative stress-related qPCR arrays.
At AnyGenes®, we provide high-performance qPCR arrays and customizable SignArrays® dedicated to oxidative stress signaling pathway analysis.
Our solutions enable researchers to:
What can be analyzed?
Scientific data is only as powerful as the analysis behind it.
AnyGenes® provides a dedicated data analysis tool specifically developed for SignArrays® pathway panels.
What does it allow you to do?
Developed on Excel (compatible with 2007+), the software is user-friendly and requires no advanced bioinformatics skills.
Customize your own signaling pathways (SignArrays®) with the factors of your choice!
Simply download and complete our Personalized SignArrays® information file
and send it at
[email protected]
to initiate your project.
Oxidative stress signaling pathways are cellular signaling mechanisms activated in response to reactive oxygen species (ROS). They regulate antioxidant defenses, inflammation, metabolism, and cell fate decisions depending on redox balance.
At controlled levels, ROS act as secondary messengers that modulate pathways such as NRF2, MAPK, NF-κB, and FoxO. Excessive ROS disrupt signaling homeostasis and cause oxidative damage.
Major oxidative stress signaling pathways include:
Dysregulated oxidative stress signaling contributes to cancer, neurodegenerative diseases, cardiovascular disorders, metabolic diseases, chronic inflammation, and aging-related pathologies.
Oxidative stress signaling pathways can be analyzed by measuring gene expression of ROS regulators, antioxidant enzymes, transcription factors, and downstream targets using targeted gene expression approaches such as qPCR pathway arrays.
| Signaling Pathways | Product ref | Informations |
|---|---|---|
Oxidative Stress | OS1H1 |
| Signaling Pathways | Product ref | Informations |
|---|---|---|
Oxidative Stress | OS1M1 |
| Signaling Pathways | Product ref | Informations |
|---|---|---|
Oxidative Stress | ******* |
Biomarker list in progress. |
| Signaling Pathways | Product ref | Informations |
|---|---|---|
Oxidative Stress | ******* |
Biomarker list in progress. |
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3. Peña-Oyarzun D et al. Autophagy and oxidative stress in non-communicable diseases: A matter of the inflammatory state?. Free Radic Biol Med. (2018) 20;124:61-78.
4. Liguori I et al. Oxidative stress, aging, and diseases. Clin Interv Aging. (2018) 26;13:757-772.
5. Simioni C et al. Oxidative stress: role of physical exercise and antioxidant nutraceuticals in adulthood and aging. Oncotarget. (2018) 30; 9(24): 17181–17198.
6. Varadharaj S et al. Role of Dietary Antioxidants in the Preservation of Vascular Function and the Modulation of Health and Disease. Front Cardiovasc Med. (2017) 1;4:64.