Understanding the HIPPO signaling pathway

The Hippo signaling pathway plays a crucial role in regulating cell growth, organ size, tissue homeostasis, and stem cell renewal. By controlling cell proliferation and apoptosis, this pathway ensures the balance between growth and cell death, preventing overgrowth and contributing to tissue regeneration.

Dysregulation of the Hippo pathway has been linked to cancer progression, fibrosis, and other pathological conditions.

Why Choose AnyGenes® for Your Research?

AnyGenes^® offers cutting-edge qPCR arrays specifically designed to study the Hippo signaling pathway. Our solutions help researchers:

Investigate key regulators such as MST1/2, LATS1/2, YAP, and TAZ.
Analyze gene expression changes involved in tissue growth and homeostasis.
Explore interactions between Hippo and other signaling pathways.

Our qPCR arrays provide high sensitivity, reproducibility, and reliable results. With advanced design and robust quality controls, AnyGenes^® supports you in uncovering novel insights into the Hippo pathway.

Discover our advanced qPCR arrays for HIPPO Pathway research.

Schematics diagram of the Hippo pathway.

Key mechanisms of the HIPPO pathway

Core Kinase Cascade: The pathway involves a kinase cascade, where MST1/2 kinases activate LATS1/2 kinases. These, in turn, phosphorylate the transcriptional co-activators YAP and TAZ, preventing them from promoting gene expression.
YAP/TAZ Regulation: When unphosphorylated, YAP and TAZ translocate to the nucleus and activate genes that drive cell proliferation and survival.
Crosstalk with Other Pathways: The Hippo pathway interacts with Wnt, TGF-β, and PI3K/Akt pathways, highlighting its central role in cellular signaling networks.

Biological functions of the HIPPO pathway

The Hippo pathway ensures cellular equilibrium and has wide-ranging implications in biology:

Regulating Organ Size: Maintains growth by balancing cell proliferation and apoptosis.
Tissue Homeostasis: Facilitates continuous cell renewal and repair processes.
Tumor Suppression: Inhibits oncogenic activity by regulating YAP/TAZ function.
Stem Cell Regulation: Controls the renewal and differentiation of stem cells.
Wound Healing: Promotes tissue regeneration following injuries.

This pathway is vital for maintaining cellular balance and has significant implications for cancer research and regenerative medicine.

The HIPPO pathway and diseases

Disruptions in Hippo pathway contribute to various diseases, including:

Cancer: Aberrant activation of YAP/TAZ drives tumorigenesis, metastasis, and therapy resistance.
Fibrosis: Excessive tissue remodeling and scarring result from Hippo pathway dysregulation.
Regenerative Disorders: Impaired Hippo pathway affects stem cell function and tissue repair mechanisms.

Advance your research with AnyGenes®

AnyGenes^® qPCR arrays offer unparalleled advantages for researchers focusing on the Hippo pathway:

Comprehensive Coverage: Our arrays include a wide range of genes and biomarkers associated with Hippo pathway and its crosstalk with other pathways.
Custom Solutions: Tailor-made arrays allow you to focus on specific targets or adapt to unique research needs.
Simplified Workflow: Streamlined protocols save time while ensuring accurate and reproducible data.
Dedicated Support: Our scientific experts provide guidance to optimize experimental design and data interpretation.

Empower your research with AnyGenes^® and drive innovations in understanding the Hippo pathway’s role in complex biological systems.

Analyze your pathway data with AnyGenes® software

Scientific data is only as powerful as the analysis behind it.

AnyGenes® provides a dedicated data analysis tool specifically developed for SignArrays® pathway panels.

What does it allow you to do?

Automated ΔCq calculation
Normalization with selected housekeeping genes
Comparison of up to 10 experimental conditions
Generation of descriptive statistics
Publication-ready graphs
Exportable tables for manuscripts and presentations

Developed on Excel (compatible with 2007+), the software is user-friendly and requires no advanced bioinformatics skills.

Customize your own signaling pathways (SignArrays®) with the factors of your choice!
Simply download and complete our Personalized SignArrays® information file and send it at [email protected] to initiate your project.

HIPPO signaling pathway biomarker list

You can check the biomarker list included in this pathway, see below:

Species : Homo sapiens (human)

Human Signaling Pathways

Signaling Pathways	Product ref	Informations
HIPPO Signaling Pathway	HIPO1H1	Download biomarker list
HIPPO Signaling Pathway	HIPO2H1	Download biomarker list

Species : Mus musculus (mouse)

Mouse Signaling Pathways

Signaling Pathways	Product ref	Informations
HIPPO Signaling Pathway	HIPO1M1	Download biomarker list
HIPPO Signaling Pathway	HIPO2M1	Download biomarker list

Species : Rattus norvegicus (rat)

Rat Signaling Pathways

Signaling Pathways	Product ref	Informations
HIPPO Signaling Pathway	*******	Biomarker list in progress.

Species : Sus Scrofa (Pig)

Pig HIPPO Signaling Pathway

Signaling Pathways	Product ref	Informations
HIPPO Signaling Pathway	*******	Biomarker list in progress.

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Bibliography

1. Wu Z, Guan KL. Hippo Signaling in Embryogenesis and Development. Trends Biochem Sci. (2021);46(1):51-63.

2. Dey A, Varelas X, Guan KL. Targeting the Hippo pathway in cancer, fibrosis, wound healing and regenerative medicine. Nat Rev Drug Discov. (2020);19(7):480-494.

3. Driskill JH, Pan D. The Hippo Pathway in Liver Homeostasis and Pathophysiology. Annu Rev Pathol. (2021);16:299-322.

4. Wang D et al. Emerging role of the Hippo pathway in autophagy. Cell Death Dis. (2020);11(10):880.

5. Wang D et al. Emerging role of the Hippo pathway in autophagy. Cell Death Dis. (2020);11(10):880.

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