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WHAT IS THE HIF-1 PATHWAY?

The Hypoxia-Inducible Factor 1 HIF-1 pathway is a crucial regulator of cellular responses to low oxygen levels (hypoxia). HIF-1 is a transcription factor composed of two subunits, HIF-1α and HIF-1β, that activate the expression of genes involved in oxygen homeostasis, angiogenesis, metabolism, and cell survival.

In hypoxic conditions, HIF-1α stabilizes and translocates to the nucleus, where it dimerizes with HIF-1β to promote the transcription of target genes.

Explore hypoxia-related gene expression with AnyGenes® HIF-1 Pathway qPCR Array, designed for precise analysis of cellular responses to low oxygen levels.

Unveiling the HIF-1 Pathway with AnyGenes® qPCR Arrays

AnyGenes® offers state-of-the-art qPCR arrays designed to analyze the HIF-1 pathway at the molecular level. Our advanced tools empower researchers to:

  • Examine gene expression changes under hypoxic conditions.
  • Identify key HIF-1 target genes, including VEGF, EPO, GLUT1, and PDK1.
  • Investigate signaling pathways such as PI3K/Akt/mTOR and MAPK that modulate HIF-1 activity.
  • Understand hypoxia-related mechanisms in cancer progression, angiogenesis, and metabolism.

Discover our advanced qPCR arrays for HIF-1 Signaling Pathway research.

The oncogenic and tumor suppressive activity of HIF in tumor and stromal cells.
The oncogenic and tumor suppressive activity of HIF in tumor and stromal cells.

KEY MECHANISMS AND TARGET GENES IN THE HIF-1 PATHWAY

The HIF-1 pathway orchestrates a wide range of biological processes crucial for cellular adaptation to hypoxia:
  • Angiogenesis: Activation of VEGF promotes the formation of new blood vessels to enhance oxygen delivery.
  • Metabolic Reprogramming: Upregulation of glycolytic enzymes and GLUT1 supports anaerobic metabolism.
  • Cell Survival: Regulation of anti-apoptotic factors ensures cell survival under low oxygen conditions.
  • Erythropoiesis: Stimulation of erythropoietin (EPO) production increases red blood cell formation.
  • Drug Resistance: Tumor cells that adapt to hypoxic stress often activate survival pathways that diminish the efficacy of conventional treatments.

HIF 1 PATHWAY AND DISEASES

The dysregulation of the HIF 1 pathway is implicated in a range of pathological conditions:

  • Cancer: Promotes tumor growth and metastasis by enhancing angiogenesis and metabolic adaptation.
  • Cardiovascular Diseases: Involved in ischemic injury, myocardial infarction, and vascular remodeling.
  • Chronic Inflammatory Diseases: Contributes to hypoxia-induced inflammation and tissue damage.
  • Metabolic Disorders: Affects glucose metabolism and insulin sensitivity.

ADVANCING HIF-1 SIGNALING PATHWAY RESEARCH WITH ANYGENES®

Our qPCR arrays provide precise and reproducible data for studying the HIF 1 pathway, helping researchers to:

  • Investigate hypoxia-driven gene expression.
  • Uncover therapeutic targets for hypoxia-related diseases.
  • Gain insights into cellular adaptation mechanisms.

Explore the complexities of the HIF 1 pathway with AnyGenes® qPCR solutions. Our tools are tailored to advance your research with accuracy and efficiency, enabling groundbreaking discoveries in hypoxia-related biology.

THERAPEUTIC APPLICATIONS

Given its central role in tumor biology, the HIF-1 pathway has emerged as a promising target for cancer therapy. Several inhibitors targeting HIF-1α are under investigation:

  • HIF-1 Inhibitors: These agents aim to disrupt the function or stability of HIF-1α, potentially enhancing the effectiveness of existing treatments and reducing tumor growth.
  • Combination Therapies: Combining HIF-1 inhibitors with other therapeutic modalities may improve patient outcomes by addressing both hypoxia-related adaptations and tumor cell proliferation.
  1. Fu X et Zhang F. Role of the HIF-1 signaling pathway in chronic obstructive pulmonary disease. Exp Ther Med. (2018);16(6):4553-4561.
  2. Jin Q et al. Hypoxia-inducible factor-1 signaling pathway influences the sensitivity of HCC827 cells to gefitinib. Oncol Lett. (2019);17(4):4034-4043.
  3. Li H et al. Targeting HIF-1α signaling pathway for gastric cancer treatment. Pharmazie.(2019);74(1):3-7.
  4. Qin Y et al. Salidroside improves the hypoxic tumor microenvironment and reverses the drug resistance of platinum drugs via HIF-1α signaling pathway. EBioMedicine. (2018);38:25-36.
  5. Huang Y et al. Hypoxia inducible factor (HIF) in the tumor microenvironment: friend or foe? Sci China Life Sci. (2017);60(10):1114-1124.
  6. Lee HJ et al. Role of HIF1α Regulatory Factors in Stem Cells. Int J Stem Cells. (2019 );12(1):8-20.
  7. Xia Y et al. The role of HIF-1α in chemo-/radioresistant tumors. Onco Targets Ther. (2018); 11: 3003–3011.

HIF-1 SIGNALING PATHWAY BIOMARKER LIST

Customize your own signaling pathways (SignArrays®) with the factors of your choice!
Simply download and complete our Personalized SignArrays® information file and send it at [email protected] to get started on your project.

You can check the biomarker list included in this pathway, see below:

Species : Homo sapiens (human)

Human signaling Pathways

Signaling PathwaysProduct refInformations

HIF-1 Signaling Pathway

HIF1H1

List infos


Species : Mus musculus (mouse)

Mouse signaling Pathways

Signaling PathwaysProduct refInformations

HIF-1 Signaling Pathway

HIF1M1

List infos


Species : Rattus norvegicus (rat)

Rat signaling Pathway

Signaling PathwaysProduct refInformations

HIF-1 Signaling Pathway

*******

List In progress...


Species : Sus Scrofa (Pig)

Pig HIF-1 Signaling Pathway

Signaling PathwaysProduct refInformations

HIF-1 Signaling Pathway

*******

List In progress...


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[email protected]